Thyrotoxic Storm Leonard Wartofsky Thyrotoxic storm or crisis is a rare, life-threatening syndrome characterized by exaggerated clinical manifestations of thyrotoxicosis (1). Its incidence is not precisely known because there are…

Behavioral and Psychiatric Aspects of Thyrotoxicosis Michael Bauer Mary H. Samuels Peter C. Whybrow When Parry first described the syndrome of hyperfunction of the thyroid gland in 1825, he attributed…

The Skeletal System in Thyrotoxicosis Graham R. Williams Regulation of Thyroid Status Circulating thyroid hormone concentrations are maintained in the euthyroid range by the hypothalamic–pituitary–thyroid (HPT) axis, a classic example…

The Male and Female Reproductive System in Thyrotoxicosis Gerasimos E. Krassas Nikolaos E. Pontikides The reproductive system has been suggested to be relatively resistant to the effects of thyroid dysfunction….

Thyroid Hormones in Thermogenesis, Intermediary Metabolism, and Obesity Thomas Reinehr Introduction Thyroid hormones can modulate numerous cellular processes that are relevant for thermogenesis, basal metabolic rate, and consequently for body…

The Cardiovascular System in Thyrotoxicosis Irwin L. Klein Sara Danzi Almost two centuries ago, Caleb Parry, an English physician from Bath, reported on the association between thyrotoxicosis and the cardiovascular…

Overview of the Clinical Manifestations of Thyrotoxicosis* Henry B. Burch Introduction There are few endocrine syndromes with as dramatic and systemic a clinical presentation as that seen with overt thyrotoxicosis….

Thyrotoxicosis of Extrathyroid Origin Angela M. Leung Joshua D. Safer Extrathyroidal causes of thyrotoxicosis can be difficult to diagnose. The most common cause is exogenous thyroid hormone ingestion or exposure….

Sporadic Painless, Painful Subacute and Acute Infectious Thyroiditis Alan P. Farwell Introduction Thyroiditis comprises a diverse group of disorders that are among the most common endocrine abnormalities encountered in clinical…

Trophoblastic Tumors Jerome M. Hershman Thyrotoxicosis occurs in patients with trophoblastic tumors, which are either hydatidiform moles or choriocarcinomas. Since the first report of thyrotoxicosis in women with a hydatidiform…