The Role of Advocacy Groups in Lung Cancer
Summary of Key Points † Deceased. • To describe the functions of advocacy. • To describe how lung cancer advocacy groups accomplish their goals. • To describe how they can…
The Role of Health Services Research in Improving the Outcomes for Patients With Lung Cancer
Summary of Key Points • Health services research aims to improve the outcomes to treatment for lung cancer by optimizing the accessibility, quality, and efficiency of treatment programs. • Achieving…
Adjuvant and Neoadjuvant Chemotherapy for Early-Stage Nonsmall Cell Lung Cancer
Summary of Key Points • Surgery remains the most effective curative approach for early-stage (IA–IIB) NSCLC. Selected cases with clinical stage IIIA disease equally benefit from radical resection. • Stereotactic…
Management of Toxicities of Targeted Therapies
Summary of Key Points • Epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), BRAF, C-ros oncogene 1 (ROS1), ret proto-oncogene (RET) tyrosine kinase inhibitors (TKIs), several antiangiogenesis agents, and…
Treatment of Extensive-Stage Small Cell Lung Cancer
Summary of Key Points • Performance status is universally recognized as an independent prognostic factor and typically correlates with the extent of tumor burden. • As first-line therapy, platinum agent…
Immunotherapy and Lung Cancer
Summary of Key Points • Immunotherapy has entered a new era in lung cancer and is rapidly changing the standard of care. • Vaccines as monotherapies have shown marginal efficacy…
New Targets for Therapy in Lung Cancer
Summary of Key Points • Treatment of lung cancer is rapidly evolving. Large cell carcinomas as a group have therapeutically relevant driver mutations in nearly 40% of cases. • Despite…
Pharmacogenomics in Lung Cancer: Predictive Biomarkers for Chemotherapy
Summary of Key Points • Discussed are tumor factors that affect treatment responses and outcome and host genetic elements that affect drug metabolism. Only pharmacogenomics elements that interact with chemotherapeutic…
Maintenance Chemotherapy for Nonsmall Cell Lung Cancer
Summary of Key Points • Maintenance therapy offers the possibility of continued active treatment to delay disease progression and symptom deterioration and, more importantly, improved overall survival of patients with…
Systemic Options for Second-Line Therapy and Beyond
Summary of Key Points • There are a growing proportion of patients who are candidates for second-line therapy and beyond. • Treatment choices are dictated by tumor histology, molecular phenotype…
