Oncohema Key

Cancer Complications TUMOR LYSIS SYNDROME Jarett L. Feldman Matthew J. Matasar Definition TLS is the metabolic abnormalities a/w spontaneous &/or tx-induced cell death that can be potentially fatal in certain…

Cancer Pharmacology PHARMACOGENETICS AND PHARMACOGENOMICS Mabel Rodriguez Introduction Pharmacogenetics: Effect of heritability on response to drugs. Study of single genes & their effects on interindividual differences in drug metabolizing enzymes….

Cancer Genetics BRCA1/2 Payal D. Shah Kenneth Offit Mark Robson Biology Genes: BRCA1 on chromosome 17q, BRCA2 on 13q Function: TSGs; proteins function in double-stranded DNA damage repair by homologous…

Cancer Immunology CANCER IMMUNOBIOLOGY Gabriela Soriano Hobbs Alexander M. Lesokhin Cancer Immunology Basics The immune system plays an important role in CA surveillance; Rx that modulate & amplify the immune…

Molecular Diagnostics SEQUENCING Chung-Han Lee Classic Sanger Sequencing Developed in 1977 by Frederick Sanger & colleagues Required reagents DNA template (what you want to seq) DNA primer (known seq) dNTPs…

Cancer Biology CANCER HALLMARKS & STEM CELLS Alexander Drilon Hallmarks of Cancer CAs share a set of common distinctive & complementary capabilities that enable tumor growth & met dissemination (Cell…

Radiation Oncology BASIC RADIATION BIOLOGY AND PHYSICS Gaorav P. Gupta Barry S. Rosenstein Definitions Ionizing Radiation (IR): Photons that have adequate energy to eject orbital electrons from target molecules X-rays:…

Clinical Research Methods PHASE I CLINICAL TRIALS Connie Lee Batlevi David R. Spriggs Phase 0 Trials Proof of concept trials designed to be first in human (Nat Rev Cancer 2007;7:131)…

General Oncology CANCER EPIDEMIOLOGY Anita Kumar Victoria Blinder Cancer Epidemiology Research Methods Epidemiology: Study of distribution, determinants, & outcomes of cancer at a population level; applies public health or policy…