Major Platelet Glycoproteins: Integrin αIIbβ3 (GPIIb-IIIa) Feng Ye Mark H. Ginsberg The first insight into the involvement of the integrin αIIbβ3 in hemostasis came from the observation that two major…
Major Platelet Glycoproteins: Platelet Glycoprotein Ib-IX-V Michael C. Berndt Robert K. Andrews In the past 5 years, understanding of the structure and function of the platelet glycoprotein (GP) Ib-IX-V complex1,2…
Thrombopoietin Kenneth Kaushansky Ian Hitchcock HISTORY The term erythropoietin (EPO) was coined at the turn of the last century to describe the humoral substance responsible for red cell production. At…
Megakaryocyte Structure and Platelet Biogenesis Joseph E. Italiano Jr. John H. Hartwig INTRODUCTION The process of making platelets is both amazing and bewildering. In the humans, 108 megakaryocytes are born…
Platelet Production: Cellular and Molecular Regulation Elisabeth Cramer BordÉ William Vainchenker Platelets are derived from the fragmentation of the cytoplasm of giant bone marrow cells, the megakaryocytes (MKs). MKs are…
Overview of Megakaryocyte and Platelet Biology Joel S. Bennett Platelets are circulating anucleate fragments of bone marrow megakaryocytes that provide primary hemostasis by forming hemostatic plugs at sites of vascular…
Inhibitors of Fibrinolysis BjÖRn Wiman Anna ÅGren The fibrinolytic system has many different functions in vivo. Within the blood vessels, its main function is to remove fibrin deposits and keep…
Plasminogen Activation and Regulation of Fibrinolysis Nicola J. Mutch Nuala A. Booth Hemostasis requires mechanisms both to stop bleeding by formation of a hemostatic plug and to dissolve this plug…
Protein C, Protein S, Thrombomodulin, and the Endothelial Protein C Receptor Pathways Laurent O. Mosnier John H. Griffin THE PROTEIN C PATHWAYS—OVERVIEW Control of coagulation reactions is essential for normal…
Antithrombin and the Serpin Family Susan C. Bock ANTITHROMBIN III Overview Antithrombin III (ATIII) is a plasma proteinase inhibitor that inactivates thrombin and the enzymes responsible for the generation of…
