Protein C, Protein S, Thrombomodulin, and the Endothelial Protein C Receptor Pathways Laurent O. Mosnier John H. Griffin THE PROTEIN C PATHWAYS—OVERVIEW Control of coagulation reactions is essential for normal…
Antithrombin and the Serpin Family Susan C. Bock ANTITHROMBIN III Overview Antithrombin III (ATIII) is a plasma proteinase inhibitor that inactivates thrombin and the enzymes responsible for the generation of…
Factor XIII CéDric Duval Helen Phiuppou Robert A.S. AriëNs Factor XIII (FXIII) is an unusual blood coagulation factor, circulating as a heterotetramer composed of two catalytic A-subunits and two noncatalytic…
Fibrinogen Structure and Function John W. Weisel Carl-Erik H. Dempfle Fibrinogen, originally factor I (FI) in the clotting cascade, is a fibrous adhesive glycoprotein, present in the plasma at a…
The Factor XII-Driven Plasma Contact System Thomas RennÉ SUMMARY The contact system is a protease cascade that is initiated by coagulation factor XII activation and operates on cardiovascular cells. The…
Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins Kanagasabai Vadivel Amy E. Schmidt Victor J. Marder Sriram Krishnaswamy S. Paul Bajaj Physiologic coagulation is initiated when, upon vascular…
Structure and Function of von Willebrand Factor Sandra L. Haberichter Robert R. Montgomery von Willebrand disease (vWD) is the most common hereditary bleeding disorder with a prevalence estimated by some…
Factor V and Factor VIII Randal J. Kaufman Philip J. Fay Laura Popolo Thomas L. Ortel Factor V and factor VIII are two homologous nonenzymatic proteins that play a critical…
Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation James H. Morrissey George J. Broze Jr. Blood circulates as a liquid, but once it escapes from an injured blood…
