Clinical Disorders of Fibrinolysis
Clinical Disorders of Fibrinolysis Daphne B. Stewart Charles W. Francis Victor J. Marder Excessive promotion or inhibition of fibrinolysis interferes with the hemostatic balance and can lead to clinical bleeding…
Familial Multiple Coagulation Factor Deficiencies
Familial Multiple Coagulation Factor Deficiencies Bin Zhang David Ginsburg The familial multiple coagulation factor deficiencies (FMFDs) are a group of rare inherited disorders characterized by a simultaneous decrease in the…
Afibrinogenemias and Dysfibrinogenemias
Afibrinogenemias and Dysfibrinogenemias Dennis K. Galanakis Congenital fibrinogen disorders have provided novel insights into structure/function relationships and into the central role of fibrinogen in hemostasis. They are generally classified as…
Rare Inherited Coagulation Disorders Other than Hemophilia
Rare Inherited Coagulation Disorders Other than Hemophilia Pier Mannuccio Mannucci Flora Peyvandi Massimo Franchini The rare inherited coagulation disorders (RICDs), usually transmitted in an autosomal recessive fashion, represent 3% to…
von Willebrand Disease: Diagnosis, Classification, and Treatment
von Willebrand Disease: Diagnosis, Classification, and Treatment J. Evan Sadler David Lillicrap von Willebrand disease (vWD) was discovered by Erik von Willebrand,1,2 a Finnish internist who investigated a family living…
Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia
Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia Edward G.D. Tuddenham Peter W. Collins T. T. Yee HISTORICAL INTRODUCTION Knowledge of a congenital bleeding disorder affecting male infants can…
Differential Diagnosis of the Bleeding Patient
Differential Diagnosis of the Bleeding Patient Jill M. Johnsen Barbara A. Konkle The hematologist is often faced with the question of whether a patient has an underlying bleeding disorder. This…
Overview of Inherited Hemorrhagic Disorders
Overview of Inherited Hemorrhagic Disorders Gilbert C. White II Harold R. Roberts Victor J. Marder The focus in Section A of Part III of this book is on inherited hemorrhagic…
Laboratory Markers of Endothelial Cell Activation and Dysfunction
Laboratory Markers of Endothelial Cell Activation and Dysfunction Eduard Shantsila Gregory Y.H. Lip Robert P. Hebbel The diverse functions of the vascular endothelium are of critical importance in maintaining physiologic…
Leukocyte Function and Contribution to Disease
Leukocyte Function and Contribution to Disease Edith Van De Vijver Taco W. Kuijpers Inflammation is a tightly regulated process initiated after tissue injury or infection. The main function of inflammation…
