Laboratory Markers of Endothelial Cell Activation and Dysfunction Eduard Shantsila Gregory Y.H. Lip Robert P. Hebbel The diverse functions of the vascular endothelium are of critical importance in maintaining physiologic…
Leukocyte Function and Contribution to Disease Edith Van De Vijver Taco W. Kuijpers Inflammation is a tightly regulated process initiated after tissue injury or infection. The main function of inflammation…
Endothelial Cell-Blood Cell Interactions Klaus Ley Interactions between monocytes, platelets, and endothelial cells are intimately involved with and are of key importance for the regulation of hemostasis, thrombosis, inflammation, and…
Heparin and Vascular Proteoglycans Douglas M. Tollefsen Lijuan Zhang Heparin is a sulfated glycosaminoglycan isolated from mammalian tissues that are rich in mast cells. When administered intravenously, heparin binds to…
Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway Wolfram Ruf Tissue and vascular injury requires a rapid hemostatic response that is critically dependent on the tissue factor (TF)-initiated extrinsic coagulation pathway….
Role of the Endothelium in Hemostasis Michael J. Krisinger Edward M. Conway Hemostasis and coagulation, which refer to the arrest of bleeding and the formation of a fibrin clot, respectively,…
Endothelial Cell Function William C. Aird The endothelium is an expansive organ, reaching all recesses of the human body. At one time, it was believed that endothelial cells (ECs) were…
Blood Vessel Wall in Health and Disease Keith R. Brunt Sonya Hui Jagdish Butany Mansoor Husain Large arteries and veins are comprised of concentric layers of smooth muscle cells (SMCs)…
Rheology and Vessel Wall Stress Larry V. Mcintire Juan M. JiméNez Suzanne G. Eskin Peter F. Davies The classical conditions considered favorable for thrombosis and attributed to the triad of…
Nitric Oxide: The Vascular Biology of Nitric Oxide and Nitric Oxide Synthases Bradley A. Maron Thomas Michel Nitric oxide (NO) is a ubiquitous, biologically versatile, and structurally unique molecule that…
