Implications of Obesity in Breast Cancer
Implications of Obesity in Breast Cancer Ayca Gucalp Patrick G. Morris Clifford A. Hudis Andrew J. Dannenberg INTRODUCTION Obesity is a major risk factor for the development of some of…
Pharmacogenomics of Systemic Therapy
Pharmacogenomics of Systemic Therapy James M. Rae INTRODUCTION TO PHARMACOGENETICS AND PHARMACOGENOMICS Over the past half century, a large number of studies on the genetic diversity of human drug response…
Adjuvant Systemic Therapy: Bone-Targeted Treatments
Adjuvant Systemic Therapy: Bone-Targeted Treatments Robert E. Coleman Bone is the most common site for distant recurrence in breast cancer and is the first location for recurrence in about one-third…
Adjuvant and Preoperative Systemic Therapy for HER2-Positive Breast Cancer
Adjuvant and Preoperative Systemic Therapy for HER2-Positive Breast Cancer Ian E. Krop Eric P. Winer INTRODUCTION HER2/neu is a member of the ErbB family of transmembrane tyrosine kinases. The family…
Adjuvant Chemo Endocrine Therapy
Adjuvant Chemo Endocrine Therapy Vered Stearns Nancy E. Davidson INTRODUCTION Adjuvant systemic therapy is associated with significant improvements in disease-free and overall survival benefits and is recommended to most women…
Adjuvant Systemic Chemotherapy in Early Breast Cancer
Adjuvant Systemic Chemotherapy in Early Breast Cancer Chau Dang Clifford A. Hudis INTRODUCTION In women, breast cancer is the most common life-threatening malignancy, but the second leading cause of cancer…
Lymphedema
Lymphedema Sarah A. McLaughlin Breast cancer-related lymphedema remains a feared complication following breast cancer treatment (1) because it is a chronic process that cannot reliably be prevented. Dramatic modifications to…
Adjuvant Systemic Therapy: Endocrine Therapy
Adjuvant Systemic Therapy: Endocrine Therapy Mothaffar F. Rimawi C. Kent Osborne INTRODUCTION TO ADJUVANT ENDOCRINE THERAPY Breast cancer causes death because of metastases in distant sites that gradually grow and…
Postmastectomy Radiation Therapy
Postmastectomy Radiation Therapy Atif Khan Bruce G. Haffty INTRODUCTION The use of postmastectomy radiation therapy (PMRT) is perhaps one of the most intensively studied topics in oncology and yet continues…
Local Management of the Axilla
Local Management of the Axilla Monica Morrow Jay R. Harris MANAGEMENT SUMMARY: AXILLA The management of the axillary lymph nodes changed dramatically with the introduction of sentinel lymph node biopsy…
