MEASUREMENT
MEASUREMENT Part of “CHAPTER 51 – PARATHYROID HORMONE“ RADIOIMMUNOASSAYS Radiommunoassays (RIAs) developed for human PTH generally do not use human PTH (hPTH) 1–84 as a tracer because of its scarcity…
PARATHYROID HORMONE RECEPTORS
PARATHYROID HORMONE RECEPTORS Part of “CHAPTER 51 – PARATHYROID HORMONE“ The PTH/PTHrP receptor is a member of the G-protein–linked receptor superfamily. These glycoproteins have hydrophobic sequences that are thought to…
ACTIONS OF PARATHYROID HORMONE
ACTIONS OF PARATHYROID HORMONE Part of “CHAPTER 51 – PARATHYROID HORMONE“ PARATHYROID HORMONE FUNCTIONS The major function of PTH appears to be the maintenance of a normal level of extracellular…
HORMONE SECRETION
HORMONE SECRETION Part of “CHAPTER 51 – PARATHYROID HORMONE“ GENERAL FEATURES OF HORMONAL SECRETION Relatively little PTH is stored in secretory granules within the parathyroid glands. In the absence of…
MOLECULAR BIOLOGY OF PARATHYROID HORMONE
MOLECULAR BIOLOGY OF PARATHYROID HORMONE Part of “CHAPTER 51 – PARATHYROID HORMONE“ CHARACTERISTICS OF THE NORMAL PARATHYROID HORMONE GENE The structural characterization of messenger RNAs (mRNAs) and genes encoding preproPTH…
BIOSYNTHESIS OF PARATHYROID HORMONE
BIOSYNTHESIS OF PARATHYROID HORMONE Part of “CHAPTER 51 – PARATHYROID HORMONE“ Parathyroid hormone follows a pattern of biosynthesis and of vectorial transport through organelles of the cell that now is…
PARATHYROID HORMONE
PARATHYROID HORMONE David Goltzman Geoffrey N. Hendy Parathyroid hormone (PTH) is essential for the physiologic maintenance of calcium homeostasis, and a marked excess or deficiency can cause severe and potentially…
SYSTEMIC HORMONES THAT AFFECT BONE METABOLISM
SYSTEMIC HORMONES THAT AFFECT BONE METABOLISM Part of “CHAPTER 50 – PHYSIOLOGY OF BONE“ Many hormones that regulate somatic growth act directly or indirectly on the skeleton. These hormones not…
EFFECTS OF HORMONES ON BONE CELLS
EFFECTS OF HORMONES ON BONE CELLS Part of “CHAPTER 50 – PHYSIOLOGY OF BONE“ Despite many studies of the direct effects of hormones on bone, the complex regulation of bone…
CELL BIOLOGY OF BONE
CELL BIOLOGY OF BONE Part of “CHAPTER 50 – PHYSIOLOGY OF BONE“ The lineages of bone-forming cells (osteoblasts) and bone-resorbing cells (osteoclasts) probably become separate early in development. Their function…
