Biology of Childhood Cancer
Biology of Childhood Cancer Christopher Denny Daniel S. Wechsler Kathleen M. Sakamoto INTRODUCTION The age-old axiom that pediatric patients are not simply small adults with disease definitely holds true in…
Molecular and Genetic Basis of Childhood Cancer
Molecular and Genetic Basis of Childhood Cancer Peter D. Aplan Jack F. Shern Javed Khan INTRODUCTION The biological behavior of every mammalian cell is determined by the pattern of gene…
Childhood Cancer and Heredity
Childhood Cancer and Heredity Sharon E. Plon David Malkin Questions often arise in the minds of parents when a child is first diagnosed with cancer: “Did this happen because of…
Epidemiology of Childhood Cancer
Epidemiology of Childhood Cancer Michael E. Scheurer Philip J. Lupo Melissa L. Bondy Epidemiology is one of the cornerstones of public health and provides a key scientific methodology for conducting…
Research Issues: Ethics and Study Design
Research Issues: Ethics and Study Design David Casarett The goal of good palliative care is to relieve suffering and to improve quality of life. However, it is apparent that access…
Measurement of Quality of Life Outcomes
Measurement of Quality of Life Outcomes Benjamin J. Miriovsky Amy P. Abernethy BACKGROUND According to the American Academy of Hospice and Palliative Medicine, the goal of palliative care is “…to…
Outcomes Assessment in Palliative Care
Outcomes Assessment in Palliative Care Joan M. Teno Accountability has been called the third revolution in medical care (1). Healthcare providers are now often faced with new questions. For example,…
Survivorship Issues in Adults
Survivorship Issues in Adults Noreen M. Aziz BACKGROUND AND SIGNIFICANCE With continued advances in strategies to detect cancer early and treat it effectively along with the aging of the population,…
Long-Term Survivorship: Late Effects
Long-Term Survivorship: Late Effects Debra L. Friedman INTRODUCTION During the last several decades, multi-modal therapy for childhood cancer has resulted in markedly improved survival and currently 80% of children are…
Hematopoietic Stem Cell Transplantation and Supportive Care
Hematopoietic Stem Cell Transplantation and Supportive Care Nina L. Bray Ann M. Berger INTRODUCTION Hematopoietic stem cell transplantation (HSCT) is a process that worldwide more than 50,000 patients undergo each…
