Measurement of Thyroglobulin
Measurement of Thyroglobulin Carole Ann Spencer Introduction Thyroglobulin (Tg) is the large (660 kDa) dimeric glycoprotein that comprises 75% of the protein content of the thyroid gland and serves as…
Measuring Serum Thyroid–Stimulating Hormone, Thyroid Hormones, Thyroid-Directed Antibodies, and Transport Proteins
Measuring Serum Thyroid–Stimulating Hormone, Thyroid Hormones, Thyroid-Directed Antibodies, and Transport Proteins Offie P. Soldin Introduction Thyroid function tests (TFTs) are among the most commonly requested laboratory tests (1). The aim…
Thyroid Radionuclide Uptake and Imaging Studies
Thyroid Radionuclide Uptake and Imaging Studies Richard L. Wahl Introduction Radionuclide imaging and uptake studies of the thyroid were once the most important procedures performed in nuclear medicine due to…
Effect of Excess Iodide: Clinical Aspects
Effect of Excess Iodide: Clinical Aspects Elio Roti Apostolos G. Vagenakis An adequate supply of dietary iodine is essential for the synthesis of the thyroid hormones. Iodine deficiency results in…
Iodine Deficiency and Endemic Cretinism
Iodine Deficiency and Endemic Cretinism Michael B. Zimmermann Introduction Bernard Courtois, a French chemist, accidentally discovered iodine (atomic weight 126.9) in 1811 while producing gunpowder for Napoleon’s army. He was…
Nonthyroidal Illness Syndrome
Nonthyroidal Illness Syndrome Wilmar M. Wiersinga Greet Van Den Berghe Changes in the regulation of the hypothalamic–pituitary–thyroid axis and in thyroid hormone transport and metabolism are common in patients with…
Effects of Drugs on TSH Secretion, Thyroid Hormones Absorption, Synthesis, Metabolism, and Action
Effects of Drugs on TSH Secretion, Thyroid Hormones Absorption, Synthesis, Metabolism, and Action Sébastien Thalmann Christoph A. Meier Introduction Various drugs and other substances are known to interfere with thyroid…
Age Related Changes in Thyroid Function
Age Related Changes in Thyroid Function Laura Boucai Martin I. Surks Introduction Life span is increasing in many countries and, as a consequence, attention has focused on the impact that…
Regulation of Thyrotropin Secretion
Regulation of Thyrotropin Secretion Anthony N. Hollenberg Thyrotropin (TSH) is the major regulator of thyroid hormone production. Measurement of serum TSH has become the principal screening test used by clinicians…
The Thyrotropin Receptor
The Thyrotropin Receptor Gilbert Vassart Thyrotropin (TSH) is a heterodimeric glycoprotein hormone composed of two subunits, an α subunit that is common to TSH, luteinizing hormone (LH), follicle-stimulating hormone (FSH),…
