Hematology in Africa
This review of hematology in Africa highlights areas of current practice and the immediate needs for development and clinical research. Acute hematological practice is dominated by anemia, sickle cell disease,…
The Present and Future Global Burden of the Inherited Disorders of Hemoglobin
The inherited disorders of hemoglobin represent the most common monogenic diseases. This article provides a brief description of the main inherited disorders of hemoglobin and their classification, and summarizes progress…
Hematological Practice in India
This article provides a short summary of hematological practice in India. It focuses particularly on how the patterns of hematologic practice differ from those of countries in the West with…
Problems and Approaches for Blood Transfusion in the Developing Countries
A safe supply of blood and the knowledge, skill, and resources for the appropriate use of blood are essential for medical services. Many problems are faced in the development of…
Glucose-6-Phosphate Dehydrogenase Deficiency
G6PD is a housekeeping gene expressed in all cells. Glucose-6-phosphate dehydrogenase (G6PD) is part of the pentose phosphate pathway, and its main physiologic role is to provide NADPH. G6PD deficiency,…
Hematological Practice in Hong Kong and China
Thalassemias and hemophilias are the most important inherited hematological diseases in Hong Kong and China. Prenatal diagnosis has significantly decreased the burden of these diseases. For thalassemia major, adequate transfusion…
Global Approach to Hematologic Malignancies
Treatment of childhood hematologic malignancies requires multidisciplinary care and reliable infrastructural support; creating a this structure in resource-poor settings remains challenging. Ideally therapy would be tailored to each region and…
Progress Toward the Control and Management of the Thalassemias
Because of the particularly high frequency of different severe forms of both α and β thalassemia in Asia, the development of approaches for their prevention and management is particularly challenging….
Sickle Cell Disease in Sub-Saharan Africa
In Africa, at least 240,000 children are born each year with sickle cell disease. Historically, in the absence of newborn screening and appropriate treatment, most such children died undiagnosed in…
The Global Burden of Anemia
Anemia is an important cause of health loss. We estimated levels and trends of nonfatal anemia burden for 23 distinct etiologies in 188 countries, 20 age groups, and both sexes…
