Prognostic Factors in Adult Acute Leukemia
The prognostic factors in adult acute leukemia have undergone a major change over the past decade and are likely to be further refined in the coming years. Age is the…
Diagnostic and Prognostic Value of Cytogenetics in Acute Myeloid Leukemia
The last 4 decades have seen major advances in understanding the genetic basis of acute myeloid leukemia (AML), and substantial improvements in survival of children and young adults with the…
Clinical Implications of Novel Mutations in Epigenetic Modifiers in AML
Increased understanding of the molecular genetics of acute myeloid leukemia (AML) has uncovered several mutations in genes with a role in the epigenetic regulation of gene transcription, including mutations in…
Acute Leukemias
Martin S. Tallman, MD, Guest Editor The acute leukemias represent a heterogeneous group of malignant hematopoietic stem cell disorders with myeloid characteristics. Remarkable insights have occurred in our understanding of…
Advances in the Use of Radiation for Gynecologic Cancers
Radiation plays an integral role in the management of gynecologic cancers. The specific regimen must be carefully coordinated based on the details of a patient’s personal history and pathologic findings….
Contemporary Quality of Life Issues Affecting Gynecologic Cancer Survivors
Regardless of cancer origin or age of onset, the disease and its treatment can produce short- and long-term sequelae (ie, sexual dysfunction, infertility, or lymphedema) that adversely affect quality of…
New Biologic Agents for the Treatment of Gynecologic Cancers
Improved understanding of the molecular basis of gynecologic cancers in addition to the availability of faster and less expensive technologies for genetic analysis of cancers has led to the exciting…
Current Management of Gestational Trophoblastic Neoplasia
Gestational trophoblastic neoplasms are malignant lesions that arise from placental villous and extravillous trophoblast. Four clinicopathologic conditions make up this entity: invasive mole (IM), choriocarcinoma (CCA), placental-site trophoblastic tumor (PSTT),…
Current Surgical Management of Ovarian Cancer
Surgical management of ovarian cancer requires excellent judgment and mastery of a wide array of procedures. Involvement of a gynecologic oncologist improves outcomes. Staging of apparent stage I disease is important….
Current Management of Vulvar Cancer
Vulvar cancer is surgically staged and is categorized by the pathologic evaluation of the vulvar tumor and the inguinofemoral lymph nodes. All tumors more invasive than 1 mm and larger…
