Myelodysplastic Syndromes
Myelodysplastic Syndromes Olga Pozdnyakova, MD, PhD Robert P. Hasserjian, MD The myelodysplastic syndromes (MDSs) are a heterogeneous group of disorders caused by a clonal expansion of hematopoietic stem cells in…
Benign Diseases of Leukocytes, Spleen, and Immunoglobulins
Benign Diseases of Leukocytes, Spleen, and Immunoglobulins Linlin Wang, MD, PhD Sonam Prakash, MBBS Benign disorders of white blood cells (WBC) can result in either quantitative or qualitative changes in…
Hemostasis and Platelet Disorders
Hemostasis and Platelet Disorders Marcia Paddock, MD, PhD John V. Mitsios, PhD Maria T. DeSancho, MD, MSc HEMOSTASIS AND ITS ROLE IN DISEASE Hemostasis Hemostasis is the process by which…
Techniques for Assessing Blood Disorders: Flow Cytometry, Multiplex Immunohistochemistry, Karyotyping, FISH, and Molecular Approaches
Techniques for Assessing Blood Disorders: Flow Cytometry, Multiplex Immunohistochemistry, Karyotyping, FISH, and Molecular Approaches Scott A. Ely, MD, MPH New techniques, platforms, and companies spring into view on a regular…
Approach to the Microscopic Evaluation of Blood and Bone Marrow
Approach to the Microscopic Evaluation of Blood and Bone Marrow Kseniya Petrova-Drus, MD, PhD Babette B. Weksler, MD EXAMINATION OF THE PERIPHERAL BLOOD Slide Preparation and Staining A hematologic evaluation…
Small Cell Lesions
Small Cell Lesions Small cell carcinomas and lymphomas constitute a common source of diagnostic error, often misclassified as anaplastic carcinomas [1, 2, 3, 4] (Figs. 13.1, 13.2, 13.3, e-Figs. 13.1,…
Squamoid, Spindle, and Giant Cell Lesions
Squamoid, Spindle, and Giant Cell Lesions UNDIFFERENTIATED (ANAPLASTIC) CARCINOMA Anaplastic or undifferentiated carcinoma historically accounted for 5% to 10% of all primary malignant tumors of the thyroid [1], but in…
Solid and Trabecular Lesions
Solid and Trabecular Lesions PAPILLARY CARCINOMA Solid Variant The solid variant of papillary carcinoma is characterized by solid nests of epithelial cells that have well-defined borders but fail to form…
Follicular Lesions
Follicular Lesions FOLLICULAR NODULAR DISEASE The most common disorder of the thyroid is the presence of numerous follicular nodules with heterogeneous architecture and cytology. These lesions may be small and…
