Pathology Post-Neoadjuvant Therapy
Definition of Pathologic Complete Response Print Section Listen A central tenet of neoadjuvant clinical trials is that tumor response, as a surrogate end point, should be strongly correlated with long-term…
Minimal Residual Cancer
Minimal Residual Cancer: Introduction Print Section Listen The genesis of overt metastases in breast cancer is based on the idea that tumor cells that dissociate from the primary cancer get…
Cytology in Breast Care Management
Cytology in Breast Care Management: Introduction Print Section Listen Cytopathology is a specialized branch of pathology related to the study of cells derived from either fine-needle aspiration biopsy (FNAB) or…
Paget Disease of the Breast
Paget Disease of the Breast: Introduction Print Section Listen An English surgeon by the name of Sir James Paget reported on a condition of eczematous change of the nipple–areola complex…
Prognostic and Predictive Factors in Breast Cancer
Prognostic and Predictive Factors in Breast Cancer: Introduction Print Section Listen Early detection and improvement in adjuvant systemic therapy has resulted in a decrease in breast cancer mortality. However, each…
Male Breast Cancer
Male Breast Cancer: Introduction Print Section Listen Males infrequently develop breast cancer; hence the dearth of prospective randomized trials in male breast cancer. Our knowledge of the disease has been…
High-Risk Lesions: ALH/LCIS/ADH
Precursor and Preinvasive Lesions of the Breast Print Section Listen The multistep model for breast carcinogenesis suggests that invasive carcinomas arise from preinvasive “hyperplastic” and neoplastic proliferations. These early proliferative…
Breast Specimen Tissue Processing
Pathology of the Breast and Clinical Management: Introduction Print Section Listen The purpose of this chapter is to provide general guidelines on specimen evaluation and highlight some clinically relevant issues,…
Prophylactic Mastectomy
Prophylactic Mastectomy: Introduction Print Section Listen Patients at increased risk of breast cancer have a range of treatment options available to decrease their risk of breast cancer development. The absolute…
Quantitative Risk Prediction
The Value of Quantitative Risk Assessment Print Section Listen There are already several approaches available to increase the chances of diagnosing breast cancer at an early, curable stage, or of…
