Chapter Outline TYPES OF DENDRITIC CELLS ORIGINS OF DENDRITIC CELLS LANGERHANS CELL HISTIOCYTOSIS Incidence Clinical Features Management Refractory Langerhans Cell Histiocytosis Reactivation Long-Term Consequences Overview of Therapeutic Options NON–LANGERHANS CELL…
Chapter Outline EPIDEMIOLOGY BIOLOGIC FEATURES Chromosomal Rearrangements in Ewing Sarcoma The Cloning of EWS/FLI EWS/FLI and Other TET/ETS Fusions in Ewing Sarcoma Ewing Sarcoma Cell of Origin EWS/FLI Target Genes…
Chapter Outline INTEGRATING PALLIATIVE CARE FROM THE TIME OF DIAGNOSIS Advantages of Early Integration of Palliative Care Enhancing Integration of Palliative Care When Cure is No Longer Possible MAKING THE…
Chapter Outline HISTORY OF PEDIATRIC ONCOLOGY NURSING Nursing Education and Professional Certification OVERVIEW OF THE PEDIATRIC ONCOLOGY NURSE’S ROLE The Nurse’s Relationship with Patients, Families, and Other Providers CARING FOR…
Chapter Outline INTRODUCTION GENERAL ISSUES RELEVANT TO INFECTIONS Risk Factors for Infection Infection Classification Intervention Approaches MAJOR PATHOGENS Bacteria Fungi Viral Infections Protozoal Infections FEVER AND NEUTROPENIA Initial Risk Stratification…
Chapter Outline PATHOLOGIC CLASSIFICATION OF RHABDOMYOSARCOMA RHABDOMYOSARCOMA IN CANCER PREDISPOSITION SYNDROMES GENETICS OF SPORADIC RHABDOMYOSARCOMA Gene Fusions Generated by Chromosomal Rearrangements Chromosome Copy Number Changes Amplification of Specific Chromosomal Regions…
Chapter Outline PRINCIPLES OF RADIATION ONCOLOGY THE PHYSICAL BASIS OF RADIOTHERAPY RADIOBIOLOGY Mechanisms of Radiation Damage Clonogenic Survival Curves The Oxygen Effect Radiation Interactions with Chemotherapeutic Agents TECHNOLOGICAL ADVANCES IN…
Chapter Outline ACUTE MYELOGENOUS LEUKEMIA Epidemiology and Etiology Biology Molecular Genetics Morphology and Cytochemistry Immunophenotype Cytogenetics Clinical Presentation Treatment Prognosis Minimal Residual Disease Relapsed or Refractory Disease ACUTE PROMYELOCYTIC LEUKEMIA…
Chapter Outline EPIDEMIOLOGY BIOLOGY OF RETINOBLASTOMA Cellular Origins of Retinoblastoma Retinoblastoma Tumor Cell Differentiation Retinoblastoma Genomics and Epigenomics Retinoblastoma Preclinical Models Retinoblastoma Translational Research GENETIC COUNSELING FOR FAMILIES WITH RETINOBLASTOMA…
Chapter Outline KEY COMPONENTS OF THE IMMUNE SYSTEM AND THEIR RELEVANCE IN CANCER IMMUNOTHERAPY Humoral Arm of the Immune System Cellular Arm of the Immune System TARGET ANTIGENS IN CANCER…
