Keywords Herpes simplex virus, immunotherapy, oncolysis, advanced cancer, vaccine Introduction Recent advances in viral genome sequencing and elucidation of viral protein function combined with a better understanding of tumor…
Keywords Adenovirus, oncolytic, immunotherapy, patients, trials, ATAP, cancer, tumor, armed viruses Overview of Oncolytic Adenoviruses Gene therapy, as described in other chapters of this book, can be used in…
Keywords Oncolytic virotherapy, brain tumors, gliomas, adenoviruses, autophagy, therapy, cancer Introduction Oncolytic virotherapy utilizes the ability of replicating viruses to selectively infect malignant cells, replicate within them, and subsequently…
Keywords Adoptive immunotherapy, dendritic cells, electropermeabilization, gene delivery systems, gene editing, gene silencing, gene transfer, hematopoietic, lentiviral vectors, LTR, mesenchymal stem cells, mitochondrion gene therapy, pseudotyping, retroviral vectors, RNAi, RRE,…
Hodgkin Disease About 7400 new cases of Hodgkin disease are diagnosed in the United States each year, with a slightly higher incidence in men. A bimodal age distribution is observed…
Cancer of the skin is the most common human malignancy, and its incidence is rising worldwide. There are approximately 900,000 to 1,200,000 new cases of skin cancer annually in the…
Acute Leukemias Acute leukemias are neoplastic disorders marked by uncontrolled proliferation of hematopoietic cells, with a predominance of immature lymphoid or myeloid cells, in the bone marrow and peripheral blood….
The Central Brain Tumor Registry of the United States (CBTRUS) estimated 51,410 new cases of malignant and nonmalignant brain tumors in 2007. Among children the incidence is 4.5 cases per…
Multiple myeloma and related disorders compose a spectrum of diseases that are characterized by the autonomous proliferation of differentiated lymphoid cells and plasma cells whose physiologic function is to secrete…
Step 1 Surgical Anatomy ♦ The adrenal gland is composed of a cortex and medulla that have different embryologic origins. ▴ The adrenal cortex arises from the coelomic mesoderm between…
