Trial purpose Aim Design Breast cancer-specific examples Breast cancer prevention To identify ways to reducing the incidence of breast cancer Cohort studies of lifestyle impacts, use of drugs in randomised…
Curative treatment Intent to cure Disease-modifying or disease-stabilizing treatment Curative treatment no longer possible Intent to prolong life and improve quality of life Palliative care Life prolonging or disease-modifying treatment…
Fig. 10.1 Columnar cell lesions. a Benign columnar cell change. The mildly dilated acini are lined by bland cells with columnar-shaped nuclei bearing apical snouts and with focal intraluminal microcalcification in…
Fig. 32.1 Preoperative photographs of an ideal candidate for a Goldilocks procedure with large, highly ptotic breasts following weight loss surgery. Scars from laparoscopic bariatric surgery are highlighted Fig. 32.2 Intraoperative photograph…
Fig. 3.1 Number of new cases and deaths per 100,00 women in the USA (Source: National Cancer Institute [7]) Data from the Global Burden of Cancer Study (GLOBOCAN) suggests that approximately…
Gene Penetrance Risk category References Breast genes ATM Moderate Higher than general population Easton DF BARD1 Moderate Higher than general population Couch FJ CDH1 High High Pharoah PD CHEK2 Moderate…
Fig. 21.1 Pre- and post-NACT MRI showing a complete clinical response Fig. 21.2 a Clip placed in the centre of the original tumour bed and b needle localization of the clip Fig. 21.3…
Fig. 60.1 Screenshot of FRAX assessment tool (© Centre for Metabolic Bone Diseases, University of Sheffield, UK. Used with permission from the University of Sheffield) 60.1.2 How Bone Health Is Monitored…
Study Patient population Treatment Results NATO (N = 605) [64] Nodal positive, premenopausal; nodal positive or negative, postmenopausal T × 2 years (N = 300) vs. No treatment (N = 305) Better PFS and OS with T…
Fig. 55.1 Forest plot of meta-analysis by Petrelli and Barni, including 15 retrospective studies that examined the association between primary site local therapy and survival in de novo stage IV…
