Reirradiation
Author technique year Median PFS post RT2 Median OS post RT2 Median PFS No RT2 Median OS No RT2 Merchant FFRT 2008 NA 67% at 5 years NA NA Merchant CSI…
Special Radiation Techniques for Pediatric Brain Tumors: Hypofractionation, Radiosurgery, and Brachytherapy
© Springer International Publishing AG 2018Anita Mahajan and Arnold Paulino (eds.)Radiation Oncology for Pediatric CNS Tumorshttps://doi.org/10.1007/978-3-319-55430-3_28 28. Special Radiation Techniques for Pediatric Brain Tumors: Hypofractionation, Radiosurgery, and Brachytherapy Susan M. Hiniker1 and Iris C. Gibbs1 (1) Department of Radiation…
Supratentorial Primitive Neuroectodermal Tumor
Fig. 7.1 Representative axial images from MRI of a 4-year-old patient with SPNET. On non-contrast T1-weighted (a), T2-weighted (b), and fluid-attenuated inversion recovery (FLAIR, c) images, tumor has isointense signal…
Medulloblastoma
Fig. 6.1 Molecular subgroups of medulloblastoma. Four molecular subgroups have been identified in children. The patient demographic and tumor characteristics are presented (Taylor et al. 2012) 6.5 Workup Children with…
Chemotherapeutic Strategies in Brain Tumors
• Intrathecal administration • Convection enhanced delivery • Blood Brain Barrier disruption • Intra-arterial administration • Intratumoral delivery Intrathecal administration of drugs like Ara-C and mafosfamide has been used in medulloblastoma, pineoblastoma, and recurrent brain…
Conformal Radiation Therapy for Pediatric CNS Tumors
Fig. 25.1 A non-coplanar 3DCRT plan on left shows a less conformal prescription dose distribution around the concave PTV in red. An IMRT plan is more conformal around the PTV…
Anesthesia for Immobilization
© Springer International Publishing AG 2018Anita Mahajan and Arnold Paulino (eds.)Radiation Oncology for Pediatric CNS Tumorshttps://doi.org/10.1007/978-3-319-55430-3_23 23. Anesthesia for Immobilization Pascal Owusu-Agyemang1 (1) Department of Anesthesiology, The University of Texas MD Anderson Cancer Center, Houston, TX,…
Surgical Principles in the Treatment of Pediatric Brain Tumors
Predictor Score Age < 2 years 3 Presence of transependymal edema 1 Moderate/severe hydrocephalus 2 Cerebral metastases 3 Preoperative estimated tumor diagnosis Medulloblastoma 1 Ependymoma 1 Dorsally exophytic brainstem glioma…
Craniopharyngioma
Fig. 16.1 This example depicts a 16-year-old female who presented with headaches, visual changes, and amenorrhea. On MRI (a), she was found to have a suprasellar mass with radiologic changes…
Epidemiology of Childhood Brain Tumors
Histologic subtype Region and reference Years Incidence rate (95% CI) All brain tumors Europe (Peris-Bonet et al. 2006) 1988–1997 2.99 United States (Ostrom et al. 2013) 2006–2010 5.26 (5.19–5.33) Japan…
