Ritonavir

Aug 11, 2016 by in INFECTIOUS DISEASE Comments Off on Ritonavir

Chapter 16 Ritonavir Sven A. Danner, MD, PhD Ritonavir (RTV) is an inhibitor of the protease enzyme encoded by the human immunodeficiency virus (HIV) (Fig. 16-1). The chemical structure of…

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Hepatitis C Infection

Aug 11, 2016 by in INFECTIOUS DISEASE Comments Off on Hepatitis C Infection

Chapter 55 Hepatitis C Infection Mark S. Sulkowski, MD Human immunodeficiency virus (HIV)-infected persons have an increased incidence of hepatitis C and an accelerated course of chronic liver disease, leading…

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Didanosine

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Chapter 6 Didanosine Raphael Dolin, MD STRUCTURE Didanosine (2′,3′-dideoxyinosine, ddI, Videx, Videx EC) is a nucleoside analog active against human immunodeficiency virus type 1 (HIV-1), HIV-2, simian immunodeficiency virus, and…

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Adrenal, Gonadal, and Thyroid Disorders

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Chapter 76 Adrenal, Gonadal, and Thyroid Disorders Joan C. Lo, MD, Morris Schambelan, MD A variety of endocrine disorders have been reported in association with human immunodeficiency virus (HIV) infection…

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Nelfinavir

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Chapter 18 Nelfinavir Miguel A. Goicoechea, MD, Richard H. Haubrich, MD Nelfinavir (Viracept) was the fourth protease inhibitor (PI) approved by the US Food and Drug Administration (FDA) for the…

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Lamivudine

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Chapter 9 Lamivudine James H. Willig, MD, Joseph J. Eron, Jr, MD STRUCTURE Lamivudine (3TC, Epivir) is the negative or cis enantiomer of 2′-deoxy-3′-thiacytidine that has antiviral activity against human…

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Indinavir

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Chapter 17 Indinavir Roy M. Gulick, MD, MPH Indinavir sulfate (IDV, L-735,524; MK-639; Crixivan) is a human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI). The drug was approved by…

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Establishing the Diagnosis of HIV Infection

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Chapter 1 Establishing the Diagnosis of HIV Infection Bernard M. Branson, MD, J. Steven McDougal, MD Treatment, especially highly active antiretroviral therapy (HAART), has dramatically improved survival for persons infected…

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