locus in cancer and aging
FIGURE 1 | The INK4-ARF signaling network. Physiologic mitogenic signals (green light, top left) stimulate the transcription of genes encoding D-type cyclins and facilitate their assembly into stable complexes with…
Reconstruction: New Breasts after Mastectomy
Chapter 11Reconstruction New Breasts after Mastectomy RECONSTRUCTION AFTER MASTECTOMY replaces the volume and shape of your breasts. In the hands of a gifted plastic surgeon, reconstruction isn’t just an operation,…
Mastectomy for Risk Reduction and Treatment
Chapter 10Mastectomy for Risk Reduction and Treatment MASTECTOMY (surgically removing the breasts) is sometimes the wisest course of treatment. Unilateral mastectomy removes one breast; bilateral mastectomy removes both. Although aggressive…
How BRCA Affects Men
Chapter 17How BRCA Affects Men LIKE WOMEN, MEN CAN INHERIT BRCA MUTATIONS from either parent. And when they do, like women, they face an increased lifetime risk of certain cancers…
Putting the Pieces Together to Make Difficult Decisions
Chapter 19Putting the Pieces Together to Make Difficult Decisions You climb a mountain, edging slowly upwards. Rock by rock, step by step, one at a time. From one point to…
Oophorectomy and Other Risk-Reducing Gynecologic Surgeries
Chapter 12Oophorectomy and Other Risk-Reducing Gynecologic Surgeries IF YOU DEVELOP OVARIAN CANCER, your treatment will involve oophorectomy, surgery to remove your ovaries. If you have a BRCA mutation, the most…
Diagnosis: Hereditary Cancer
Chapter 18Diagnosis Hereditary Cancer JUST TWO GENERATIONS AGO, cancers were rarely discovered until they were well advanced, almost always with dismal outcome. There is still much we don’t know, but…
Breast and Ovarian Cancer Basics
Chapter 1Breast and Ovarian Cancer Basics FROM A STRICTLY SCIENTIFIC PERSPECTIVE, women have breasts to feed their babies. Yet, for most of us, our breasts are much more than milk-producing…
