Fig. 18.1 Chronic alcohol consumption-induced inhibition on B16BL6 melanoma metastasis is IFN-γ-dependent. (a) Images showing colonies of melanoma (black dots) on the lung of water-drinking mice and alcohol-consuming mice. (b,…
Fig. 6.1 Iron accumulation and ROS are important factors in the alcohol-mediated hepatocarcinogenesis 6.2 Health Statistics of ALD Chronic alcohol consumption is one of the major risk factors worldwide, significantly…
Fig. 7.1 Five-year cumulative incidence of HCC in different etiologies of liver cirrhosis (Data from Fattovich et al., Gastroenterology 2004;127:S35-50) Obviously, structural and functional abnormalities pertinent to alcoholic cirrhotic transformation…
Fig. 12.1 Alcohol and HCV in liver disease: common sites of action 12.2 Alcohol, HCV and Innate Immunity The immune response is a common target of both alcohol and the…
Fig. 21.1 Tumor incidence in two models of HCC and EtOH consumption. (a) Twenty-one-day-old male C57BL/6 or B6C3 mice were injected with vehicle (Veh; 100 μL sterile olive oil) or…
Fig. 17.1 CEA processing and metastatic potential of colorectal cancer cells (CRC) in the alcohol-injured liver. (a) The potential effects of alcohol on the direct processing of CEA by Kupffer…
Fig. 5.1 The reaction of acetaldehyde with deoxyguanosine results in the formation of N2-ethylidendene-dG; this unstable Schiff base can be converted through a reduction step to the more stable form:…
Reference Gender Age FASD Cancer type [7] M 28 months Yes Neuroblastoma [11] F 3 years 9 months Yes, with hydantoin Hodgkin disease [33] F 12years 11 months Yes Adrenal…
Group Tumor foci Adenoma % Incidence Multiplicity % Incidence Multiplicity Chow + DEN (n = 17) 16/17 = 94 100/17 = 5.8a 1/17 = 6 2/17 = 0.1a PF + DEN (n = 18) 18/18 = 100* 209/18 = 11.6b 10/18 = 55* 15/18 = 0.8b EtOH + DEN (n = 15) 16/15 = 100* 266/15 = 17.7c 9/15 = 60* 33/15 = 2.2c % Incidence = number…
Fig. 16.1 ALDHs modulate carcinogenesis by metabolizing acetaldehyde and retinaldehyde. Ethanol is metabolized by alcohol dehydrogenase (ADH), catalase, and CYP2E1 to acetaldehyde. Acetaldehyde can interfere with antioxidative defense systems (AODS)…
