Fig. 23.1 Inhibition of tumorsphere formation by CQ Conclusions Since small subpopulations of CSCs were identified from blood mononuclear cells in human acute myeloid leukemia in 1997, it has attracted…
Fig. 7.1 Overexpression of TG2 (left panel) in epithelial cells (shown are MCF10A mammary epithelial cells) is associated with their transdifferentiation into mesenchymal looking cells (EMT; a), increased invasion (through…
Fig. 4.1 Illustration of microenvironmental factors involved in CLL survival 4.3 Role of Apoptosis Pathway Members in CLL Pathophysiology Based on their structure and/or functional homology, major protein groups of…
Fig. 16.1 Schematic representation of the mitochondrial respiratory chain The concept of ‘aerobic glycolysis’ suggested by Warburg implies that cancer cells predominantly depend on glycolysis for energy production and to…
Fig. 22.1 Medicinal plants used in traditional Korean medicine for cancer prevention and therapy According to the theory of TKM, common causes that impede healthy living are an excess of…
© Springer International Publishing Switzerland 2015Varsha Gandhi, Kapil Mehta, Rajesh Grover, Sen Pathak and Bharat B. Aggarwal (eds.)Multi-Targeted Approach to Treatment of Cancer10.1007/978-3-319-12253-3_21 21. Chemopreventive and Anticancer Efficacy of Silibinin Against Colorectal Cancer Sushil Kumar1, Komal Raina1, 2 and Rajesh Agarwal1,…
Edwin Smith Papyrus (3000 BC) Described a breast cancer-like disease Eberus Papyrus (1500 BC) Described soft tissue tumors and used cautery, knives, salts, and arsenic paste to treat this Hippocrates…
Fig. 19.1 G protein-coupled receptor (GPCR) that is coupled to a Gq heterotrimeric G protein, on binding with the ligand induce activity in the PLC (phospholipase C) isozyme PLC-β, which…
Fig. 6.1 Schematic representation of OPN structure and its receptors. OPN contains binding sites for different integrins at N-terminus and CD44 receptors at C-terminus. It also encompasses calcium-binding site and…
Fig. 18.1 Schematic representation of targets of telomerase and telomere structure for various anticancer strategies Table 18.1 Telomere- and telomerase-associated proteins and their inhibitors Target Approach Mechanism and consequence Examples…
