Emetic risk category Phase Guideline recommendations MASCC/EMSO NCCN ASCO I. High (>90 %) risk Acute 5-HT3RA (palonosetron) + DMZ + APR (or FOS) 5-HT3RAa + DMZ (12 mg) + APR (125 mg) 5-HT3RA (palonosetron) + DMZ + APR Delayed DMZ + APR DMZ (8…
National Comprehensive Cancer Network “Episodic pain not controlled with [an] existing pain regimen” [6] Oxford Textbook of Palliative Medicine “A transitory exacerbation of pain experienced by the patient who has…
© Springer International Publishing Switzerland 2016David Alberts, Maria Lluria-Prevatt, Stephanie Kha and Karen Weihs (eds.)Supportive Cancer Care10.1007/978-3-319-24814-1_1 1. Introduction David Alberts1 , Maria Lluria-Prevatt2 , Stephanie Kha2 and Karen Weihs2 (1) College of Medicine, University of Arizona, Tucson, AZ, USA (2) University of…
Method Application Effectiveness Comments and references Opioids Somatic pain Neuropathic pain Mixed pain In one underpowered randomized trial, methadone had no more effect than morphine in neuropathic pain Adjuvant drugs…
© Springer International Publishing Switzerland 2016David Alberts, Maria Lluria-Prevatt, Stephanie Kha and Karen Weihs (eds.)Supportive Cancer Care10.1007/978-3-319-24814-1_6 6. Survivorship Care Planning Darcy Burbage1 (1) Department of Psychosocial Oncology and Survivorship, Helen F Graham Cancer Center and Research Institute,…
© Springer International Publishing Switzerland 2016David Alberts, Maria Lluria-Prevatt, Stephanie Kha and Karen Weihs (eds.)Supportive Cancer Care10.1007/978-3-319-24814-1_3 3. Psychosocial Oncology Karen Weihs1, 2, 3, 4 (1) Department of Psychiatry, University of Arizona, Tucson, AZ, USA (2) Department of…
Conserved catalytic domain Activity Localization Principal targets under stress Regulation by CR/ROS Sirtuin function References Deacetylase Nucleus/cytoplasm H4K9Ac, H4K16Ac, SUV39h1, XPA, XPC, NBS1, hMOF, TIP60, WRN, Ku70, Rb, FOXO, HIF-1α,…
Fig. 16.1 Three-dimensional structure of VDAC1 and its channel activity. (A), VDAC1 monomer and dimer structures: (a) Side view of the crystal structure of VDAC1 (PDB code: 3EMN). The β-barrel…
Fig. 2.1 Synthetic lethality. (a) Idealized DNA repair pathways in a normal cell that process a specific DNA lesion, with primary and secondary pathways catalyzed by enzymes 1–3 or a–c,…
Fig. 18.1 The pro-inflammatory/suppressive phenotype of TERS-imprinted myeloid cells. The characteristics of TERS-imprinted bone marrow-derived macrophages (middle) are compared with those of canonical characteristics of M1 (left) and M2 (right)…
