Treatment in HPV-Induced Recurrent or Metastatic HNSCC
Study Method Tested Positive (%) Citation SPECTRUM P16 443 99 (22 %) Vermorken et al., Lancet Oncol (2013) EXTREME P16 381 41 (12 %) Vermorken et al., Ann Oncol (2014) EXTREME HPV…
Papillomavirus (HPV): A Criterion for Therapeutic Decision in Squamous Cell Carcinoma of the Head and Neck?
Authors Year No.pts Subsite % HPV Treatment HR Gillison et al. 2000 252 H&N 25 Surg a/o RT 0.40 Licitra et al. 2006 90 OPC 19 Surg ± RT 0.26 Fakhry et…
of HPV-Positive Tumors in Europe and in the World
Fig. 1 HPV-attributable fractions for head and neck cancers according to positivity and/or over-expression of selected biomarkers of HPV-induced carcinogenesis Figure 2 shows oropharyngeal HPV-AFs by geography, gender, age group, and year of…
in Head and Neck Cancer—30 Years of History
Reference Lesion No. of cases Method HPV-positivity Types detected Syrjänen et al. (1983a, b, c, d) SCC 40 ICH 8/40 20 % Syrjänen et al. (1983a, b, c, d) SCC 1…
Integration in Head and Neck Squamous Cell Carcinomas: Cause and Consequence
Fig. 1 a Schematic overview of HPV infection and integration during the development of HPV-positive tumors (modified from Woodman et al. 2007; Cornet et al. 2015). HPV is thought to access…
for Gliomas
Fig. 1 Motor and sensory direct cortical stimulation data. Rendering of left and right hemisphere positive stimulation sites eliciting movement (green) and dysesthesias (yellow) within the precentral and postcentral gyri, respectively….
of Gliomas
Fig. 1 Age-standardized incidence rates of malignant brain tumors (males and females combined) per 100,000 persons in 2012 by country (GLOBOCAN) Fig. 2 Age-standardized incidence rates of malignant brain tumor per 100,000…
and Supportive Care for Glioma Patients
The goals of palliative care include: • Provides relief from pain and other distressing symptoms • Affirms life and regards dying as a normal process • Intends neither to hasten…
Biology and Molecular Markers
21. Gronych J, Korshunov A, Bageritz J, Milde T, Jugold M, Hambardzumyan D, Remke M, Hartmann C, Witt H, Jones DT, Witt O, Heiland S, Bendszus M, Holland EC, Pfister…
in the Elderly
Class^ Median overall survival (months) 2-year survival (%) 1 58 76 2 37 68 3* 18 35 4* 11 15 5* 9 6 6* 4.5 4 Legend ^Class defined by…
