in Head and Neck Cancer—30 Years of History
Reference Lesion No. of cases Method HPV-positivity Types detected Syrjänen et al. (1983a, b, c, d) SCC 40 ICH 8/40 20 % Syrjänen et al. (1983a, b, c, d) SCC 1…
Integration in Head and Neck Squamous Cell Carcinomas: Cause and Consequence
Fig. 1 a Schematic overview of HPV infection and integration during the development of HPV-positive tumors (modified from Woodman et al. 2007; Cornet et al. 2015). HPV is thought to access…
for Gliomas
Fig. 1 Motor and sensory direct cortical stimulation data. Rendering of left and right hemisphere positive stimulation sites eliciting movement (green) and dysesthesias (yellow) within the precentral and postcentral gyri, respectively….
of Gliomas
Fig. 1 Age-standardized incidence rates of malignant brain tumors (males and females combined) per 100,000 persons in 2012 by country (GLOBOCAN) Fig. 2 Age-standardized incidence rates of malignant brain tumor per 100,000…
and Supportive Care for Glioma Patients
The goals of palliative care include: • Provides relief from pain and other distressing symptoms • Affirms life and regards dying as a normal process • Intends neither to hasten…
Biology and Molecular Markers
21. Gronych J, Korshunov A, Bageritz J, Milde T, Jugold M, Hambardzumyan D, Remke M, Hartmann C, Witt H, Jones DT, Witt O, Heiland S, Bendszus M, Holland EC, Pfister…
in the Elderly
Class^ Median overall survival (months) 2-year survival (%) 1 58 76 2 37 68 3* 18 35 4* 11 15 5* 9 6 6* 4.5 4 Legend ^Class defined by…
Therapy of Glioblastoma
Trial Patients (% GBM) Treatment Med. survival (months) P value BTSG 66-01 [4] 96 (85 %) No radiotherapy 3.5 <0.05 WBRT < 5000 cGy 7.7 WBRT ≥ 5000 cGy 8.4 BTSG 69-01 [3] 222 (90 %) No radiotherapy…
for Malignant Gliomas
Trial Vaccine Type Phase Experimental design N PFS (mo) OS (mo) NCT00612001 [32] DC I Autologous DC + selected glioma antigens 6 9.6 18.1 NCT00846456 [59] DC I/II Autologous DC transfected with…
Chemotherapeutic Approaches in Adult High-Grade Gliomas
Fig. 1 Schematic representing select targeted therapies for which clinical trial results are available in high-grade gliomas. Edited with permission from Lee et al. “current and future directions for Phase II…
