and Christian Waldherr1 (1) Bern, Switzerland Two-dimensional (2D) mammography screening programs reduce breast cancer mortality substantially, but they do not depict all cancers early enough to result in a cure….
and Christian Waldherr1 (1) Bern, Switzerland 1.1 Motivation for Tomosynthesis Mammography is X-ray imaging of the breast. The technique works because different components of the breast absorb X-rays in different…
Fig. 18.1 Chemical structures of cytidine and the cytidine analogs azaC (azacytidine) and DAC (aza-2′-deoxycytidine). The modifications of nitrogen in the base are depicted with red color. The red arrow…
Fig. 11.1 PML-RARα chimeric protein generated by t(15;17)(q22;q21) in APL. The chimeric PML-RARα protein retains critical domains of PML and RARα and promotes development of APL. PML-RARα fusion protein affects…
Fig. 9.1 CC chemokine receptor 4 (CCR4) and humanized anti-CCR4 monoclonal antibody, KW-0761. The CCR4 gene is located on chromosome 3p24. CCR4 is a seven-domain transmembrane G protein-coupled receptor, and…
Fig. 2.1 Timeline of BCR-ABL findings and development of imatinib 2.2 Molecular Biology of CML 2.2.1 Ph Chromosome The Ph chromosome results from a reciprocal translocation, which involves the BCR…
Response Definitions Hematologic response (HR) Complete hematologic response (CHR) WBC <10 × 109/L Platelet count <450 × 109/L Basophil <5% No immature cells Spleen nonpalpable Cytogenetic response (CyR) Complete cytogenetic…
Fig. 16.1 Structures of deoxyadenosine, cladribine, fludarabine, and clofarabine The basis of selectivity with antiviral agents usually involves selective activation by an enzyme expressed by the virus or selective inhibition…
Fig. 13.1 Timeline of the use of arsenic 13.2 Dosage, Schedule, and Pharmacokinetics of Arsenic Trioxide 13.2.1 Dosage and Administration For remission induction, ATO is administered by a 2-h infusion…
Fig. 4.1 Chemical structures of ABL tyrosine kinases. a Imatinib mesylate, b dasatinib, c nilotinib, d bosutinib, e bafetinib, f ponatinib Point mutations within the ABL kinase domain, which interfere…
