PET Radiotracers for Tumor Imaging
Fig. 1.1 [18F]FDG Although PET facilities are rapidly increasing worldwide, the only PET radiopharmaceutical currently available for diagnosis is [18F]FDG. In keeping with this notion, [18F]FDG is by far the…
Theranostic Approaches for Pathway-Activated Systems in Oncology
Diagram 2.1 Epigenetic dysregulation of the metabolic signaling pathways that control cell growth, survival, and chemoresistance mechanisms in DLBCL. Our previous studies have shown that deregulated NF-kB, NFAT, and STAT3…
Clinical Evaluation of Focused High-Resolution Breast PET
Fig. 9.1 Types of dedicated breast PET scanners. (a) Positron emission mammography (PEM). (b) Fully tomographic dedicated breast PET with dual-plate detector rotating around the breast. (c) Fully tomographic dedicated…
Optimization of Aseptic Production in PET Radiopharmaceuticals for Compliance to the Most Current GMP
Grade At rest In operation 0.5 pe 5.5 m 0.5 pe 5.5 A 3520 20 3520 20 B 3520 29 352,000 2900 C 352,000 2900 3,520,000 29,000 D 3,520,000 29,000…
Visualization of Apoptosis: Annexin V Imaging
Imaging system Isotope Radiotracer Applied animal model Reference SPECT 99mTc 99mTc-BTAP-AnnexinV Atrial thrombi {Stratton, 1995 #4} {Narula, 2001 #5} 99mTc-HYNIC-Annexin V Jurkat T-cell lymphoblasts {Blankenberg, 1999 #3} {Blankenberg, 1999 #3}…
Ethics, Regulations, and Clinical Development of Precision Medicine: Activating with Molecular Imaging
Fig. 6.1 Constructions of guidance documents by FDA concerning medical imaging drug development and radioactive drug clinical research 6.3.1.3 Clinical Trial Network and Standardization Accordingly, more and more quality assurance…
Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics
Fig. 12.1 Panel (a) illustrates the pattern of spontaneous systemic metastases that can arise heterogeneously in mice within a month or more after surgical resection of an established primary orthotopic…
The Use of Pediatric Patient-Derived Xenografts for Identifying Novel Agents and Combinations
Fig. 11.1 Schema for testing agents through the Pediatric Pre-clinical Testing Program (PPTP). Adapted from reference [68] Standard Cytotoxic Agents Responses to standard cytotoxic agents (vincristine, cyclophosphamide, actinomycin D, cisplatinum,…
3D Cell Culture Models
Fig. 19.1 Representative image of a spheroid showing the key features. MCF7 cells seeded at 5000 cells per well in a 96-well ULA plate exhibited a tight spheroid after 96…
Fluorescence Imaging of Tumors in Human Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models
Fig. 15.1 (a) Human pancreatic-cancer-patient tumor with RFP and GFP stromal cells. Image was obtained with the Olympus FV1000. Green arrows indicate GFP stromal cells from GFP mouse. Red arrows…
