Development of Hypoxia: Activated Cytotoxic Prodrug
Tumor type Tumor tissue median pO2 mm Hg (patients) Normal tissue median pO2 mm Hg Pancreas 2 (8 pts) 57 Brain 13 (104 pts) 26 Head and Neck 10 (592…
Pylorus-Resecting Pancreaticoduodenectomy
Fig. 7.1 Dissection around the pylorus ring; the right gastric artery is dissected by the root, and the first pyloric branch is dissected along the lesser curvature of the stomach….
Development of Cancer Vaccine and Targeted Immune Checkpoint Therapies
Type of immunotherapy Passive or active Example Advantages Disadvantage References Adaptive cellular therapy TIL Passive N/A Limited TILs for in vitro expansion A personalized approach and costly N/A CAR-T Passive Mesothelin…
Distal Pancreatectomy for Pancreatic Carcinoma
© Springer Science+Business Media Singapore 2017Hiroki Yamaue (ed.)Innovation of Diagnosis and Treatment for Pancreatic Cancerhttps://doi.org/10.1007/978-981-10-2486-3_12 12. Distal Pancreatectomy for Pancreatic Carcinoma Masayuki Sho1 and Shoichi Kinoshita1 (1) Department of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara Nara,…
Liquid Biopsy for Early Detection of Pancreatic Cancer
Fig. 5.1 Liquid biopsy in pancreatic cancer. Tumor-specific alterations can be detected in circulating tumor DNA (ctDNA) in blood. Detecting ctDNA in plasma or serum serves as a “liquid biopsy,”…
Pathology of Non-epithelial Ovarian Tumors
Sex cord-stromal tumors Pure stromal tumors Fibroma Cellular fibroma Thecoma Luteinized thecoma associated with sclerosing peritonitis Fibrosarcoma Sclerosing stromal tumor Signet-ring stromal tumor Microcystic stromal tumor Leydig cell tumor Steroid…
Pathology of Epithelial Ovarian Tumors
Fig. 5.1 Serous tubal intraepithelial carcinoma. Proliferation of epithelial cells with high-grade atypia replaces the surface of tubal fimbrial epithelium. (a) low power, (b) high power Fig. 5.2 p53 signature….
Epidemiology and Etiology of Ovarian Cancer
Type <20 years 20–50 years >50 years Coelomic epithelium 29% 71% 81% Germ cell 59% 14% 6% Specialized gonadal stroma 8% 5% 4% Non-specific mesenchyme 4% 10% 9% Some patients with ovarian cancer…
Management of Ovarian Cancer in Adolescents and Young Adults
SEER (NCI) 15–29-year-old Adolescent and young Adult Oncology Progress Review Group 15–39-year-old NCCN 15–39-year-old 15.3 Cancer in AYAs Worldwide Including Ovarian Cancer In the United States, 70,000 AYAs are diagnosed…
Strategies for the Management of Epithelial Ovarian Borderline Tumors
Fig. 9.1 Serous borderline tumor, micropapillary pattern. Non-hierarchial pattern is shown with micropapillary projection five times longer than width at least 5 mm in dimension with fibrous stalks The prognosis…
