Chemotherapy for Diffuse Low Grade Gliomas
Year Authors and journal N Tumor type Contrast enhancement (%) Prior RT (%) Prior CT (%) Chemotherapy regimen Response rate CR + PR/MR (%) One year PFS (%) Median PFS…
Natural History and Spontaneous Prognostic Factors
Fully validated in clinical trials • Age >40 years • Presence of neurological deficits and/or absence of seizures at onset • Low performance status (Karnofsky <70) • Preoperative tumor diameter >4–6 cm • Astrocytoma as…
Quality of Life in Patients with Diffuse Low-Grade Glioma
© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_13 13. Quality of Life in Patients with Diffuse Low-Grade Glioma Martin Klein1 (1) Department of Medical Psychology, VU University Medical Center, De Boelelaan 1118,…
Towards an Intermediate Grade in Glioma Classification
Fig. 5.1 Three examples (a = case 1; b = case 2; c = case 3) of microfoci of “intermediate grade” at low magnification (left) and at high magnification (right)…
The Genomics of Diffuse Low-Grade Gliomas
Molecular markers Prevalence (n > 1000 glioma subjects) (%) IDH mutation only 45 Triple-positive [TERTp-mut, IDH-mut, 1p/19q codeletion] 29 TERTp-mutation only 10 Triple negative [TERTp- wild type, IDH-wild type, 1p/19q…
Dissemination of Diffuse Low-Grade Gliomas: Tools and Molecular Insights
Fig. 7.1 (a) Photograph of a grade II diffuse glioma culture maintained 2 weeks after resection. (b) Detection of cells expressing the mutated form of IDH1 with R132H specific antibody….
Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Patients with Diffuse Low-Grade Gliomas
© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_1 1. Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Patients with Diffuse Low-Grade Gliomas Hugues Duffau1, 2 (1) Department…
Pathogenesis of Diffuse Low-Grade Gliomas
Type-1 Type-2 Type-3a Type-3b Clinical characteristics Age, median (IQR), y 45 (36–54) 36 (30–44) 43 (28–49) 57 (46–64) OS, mean (95% CI), y 16.38 (14.15–NA) 7.88 (6.76–9.70) 9.13 (5.05–NA)…
Minimally Invasive Surgery for Endometrial Cancer
Fig. 7.1 Surgeon’s console Fig. 7.2 Patient cart Robotic surgery enables surgeons to be more precise, advancing their technique and enhancing their capability in performing complex minimally invasive surgery. Binocular…
Diagnosis and Pre-management Workup of Endometrial Carcinoma
Fig. 5.1 Tamoxifen-induced cystic hyperplasia of the endometrium Hence, in asymptomatic women, there is a poor correlation between ultrasonographically measured endometrial thickness and abnormal pathology, and screening them has not…
