The Origins of Diffuse Low-Grade Gliomas
Fig. 34.1 Tumor overlap map overlaid on a standard Montreal National Institute (MNI) T1 for all 198 patients, presented according to the neurological convention (left to left and right to…
Interactions Between Diffuse Low-Grade Glioma (DLGG), Brain Connectome and Neuroplasticity
Fig. 22.1 Proposal of a hodotopical model of functional connectivity in the human brain, with incorporation of anatomical constraints. This networking model was elaborated on the basis of structural-functional correlations…
Task-Based and Resting-State Functional MRI in DLGG
Fig. 19.1 Motor fMRI. A low grade glioma was located in the right superior frontal gyrus, anteriorly to the precentral sulcus. Presurgical fMRI shows primary sensorimotor activation of the left…
Molecular Epidemiology of Diffuse Low-Grade Glioma
Fig. 3.1 Low-grade glioma classification algorithm according to new WHO guidelines [1] 3.2.2 Integrative Molecular Classification In additional efforts to construct clinically-relevant and objective tumor subclasses, two recent landmark studies…
Clinical Presentation in Diffuse Low-Grade Gliomas
Fig. 11.1 MRI of a patient with an oligodendroglioma WHO grade II in the right frontal pole. A right frontal lobectomy was performed with en-bloc removal of the tumor. Postoperative…
Molecular-Genetic Classification of Gliomas and Its Practical Application to Diagnostic Neuropathology
Fig. 4.1 (a) This infiltrating astrocytoma has hyperchromatic elongated astrocytic nuclei as often seen in the prototypic infiltrating astrocytomas but a significant proportion of tumor cells exhibit abundant globose eosinophilic…
The Concept of Onco-Functional Balance in the Management of DLGG
Fig. 33.1 Axial FLAIR-weighted MRI showing a typical illustration of a “false DLGG”, which is in fact a highly diffuse glioblastoma. In its initial phase of low density (left), such…
Emerging Therapies for Diffuse Low Grade Glioma
© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_29 29. Emerging Therapies for Diffuse Low Grade Glioma James Wright1 and Andrew Edward Sloan1, 2, 3 (1) Department of Neurological Surgery, University Hospitals-Cleveland Medical Center and…
New Individualized and Dynamic Therapeutic Strategies in DLGG
Fig. 28.1 Personalized dynamic multimodal therapeutic strategy in DLGG, with the goal to prevent malignant transformation while preserving quality of life 28.2.1 The Multistage Surgical Attitude As extensively demonstrated in…
Functional Rehabilitation in Patients with DLGG
© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_27 27. Functional Rehabilitation in Patients with DLGG Guillaume Herbet1, 2, 3 and Sylvie Moritz-Gasser1, 2, 4, 3 (1) National Institute for Health and Medical Research…
