© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_29 29. Emerging Therapies for Diffuse Low Grade Glioma James Wright1 and Andrew Edward Sloan1, 2, 3 (1) Department of Neurological Surgery, University Hospitals-Cleveland Medical Center and…
Fig. 28.1 Personalized dynamic multimodal therapeutic strategy in DLGG, with the goal to prevent malignant transformation while preserving quality of life 28.2.1 The Multistage Surgical Attitude As extensively demonstrated in…
© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_27 27. Functional Rehabilitation in Patients with DLGG Guillaume Herbet1, 2, 3 and Sylvie Moritz-Gasser1, 2, 4, 3 (1) National Institute for Health and Medical Research…
Fig. 26.1 Proton radiotherapy plan (left) compared to a photon plan with IMRT (right). The proton plan demonstrates decreased low dose spill (green and blue colorwash) compared to the IMRT…
Year Authors and journal N Tumor type Contrast enhancement (%) Prior RT (%) Prior CT (%) Chemotherapy regimen Response rate CR + PR/MR (%) One year PFS (%) Median PFS…
Fully validated in clinical trials • Age >40 years • Presence of neurological deficits and/or absence of seizures at onset • Low performance status (Karnofsky <70) • Preoperative tumor diameter >4–6 cm • Astrocytoma as…
© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_13 13. Quality of Life in Patients with Diffuse Low-Grade Glioma Martin Klein1 (1) Department of Medical Psychology, VU University Medical Center, De Boelelaan 1118,…
Fig. 5.1 Three examples (a = case 1; b = case 2; c = case 3) of microfoci of “intermediate grade” at low magnification (left) and at high magnification (right)…
Molecular markers Prevalence (n > 1000 glioma subjects) (%) IDH mutation only 45 Triple-positive [TERTp-mut, IDH-mut, 1p/19q codeletion] 29 TERTp-mutation only 10 Triple negative [TERTp- wild type, IDH-wild type, 1p/19q…
Fig. 7.1 (a) Photograph of a grade II diffuse glioma culture maintained 2 weeks after resection. (b) Detection of cells expressing the mutated form of IDH1 with R132H specific antibody….
