Alpha Radionuclide Therapy: Principles and Applications to NETs
Radionuclide T1/2 (h) Emission Energy deposited (MeV maximum)a Source Ra-223 273.6 4 Alpha 2 Beta 4 Gamma 2 X-ray Alpha 5.6, 6.8, 7.4, (6.6 or 7.50) Beta 0.48, 0.50 Gamma,…
131I-Meta-Iodobenzylguanidine Therapy for Pheochromocytoma/Paraganglioma and Neuroblastoma
Fig. 19.1 Structural similarities of adrenaline (upper molecule), noradrenaline (middle molecule), and 131I-mIBG (lower molecule) 19.1.2 mIBG: Uptake Mechanism Meta-iodobenzylguanidine moves into cells by the mechanism of noradrenaline reuptake of…
Molecular Genetics of Neuroblastoma
Fig. 5.1 Landscape of genetic variation in high-risk neuroblastoma (Nature Genetics 2013). MYCN amplification, deletion of chromosomes 1p, 3p, and 11q, gain of chromosomes 1q, 2p, and 17q, as well…
Molecular Genetics of Gastroenteropancreatic Neuroendocrine Tumours
© Springer International Publishing Switzerland 2017Karel Pacak and David Taïeb (eds.)Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine TumorsContemporary Endocrinology10.1007/978-3-319-46038-3_6 6. Molecular Genetics of Gastroenteropancreatic Neuroendocrine Tumours Samuel Backman1 and Peyman Björklund1 (1) Experimental Surgery, Department of Surgical…
Bridging Between Experiments and Equations: A Tutorial on Modeling Excitability
Chapter 1Bridging Between Experiments and Equations: A Tutorial on Modeling Excitability David P. McCobb1 and Mary Lou Zeeman2 1Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA 2Department of…
Endoplasmic Reticulum- and Plasma-Membrane-Driven Calcium Oscillations
Chapter 3Endoplasmic Reticulum- and Plasma-Membrane-Driven Calcium Oscillations Arthur Sherman Laboratory of Biological Modeling, NIDDK, National Institutes of Health, USA 3.1 Introduction Calcium () is of great importance throughout biology because…
A Mathematical Model of Gonadotropin-Releasing Hormone Neurons
Chapter 4A Mathematical Model of Gonadotropin-Releasing Hormone Neurons James Sneyd, Wen Duan and Allan Herbison Department of Mathematics, University of Auckland, New Zealand Department of Physiology, University of Otago, New…
Ion Channels and Electrical Activity in Pituitary Cells: A Modeling Perspective
Chapter 2Ion Channels and Electrical Activity in Pituitary Cells: A Modeling Perspective Richard Bertram, Joël Tabak and Stanko S. Stojilkovic Department of Mathematics and Program in Neuroscience, Florida State University,…
Modeling Spiking and Secretion in the Magnocellular Vasopressin Neuron
Chapter 5Modeling Spiking and Secretion in the Magnocellular Vasopressin Neuron Duncan J. MacGregor and Gareth Leng Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK 5.1 Background 5.1.1 Neurons, physiology,…
Dynamics of the HPA Axis: A Systems Modeling Approach
Chapter 8Dynamics of the HPA Axis: A Systems Modeling Approach John R. Terry, Jamie J. Walker, Francesca Spiga and Stafford L. Lightman College of Engineering, Mathematics and Physical Sciences*, University…
