Rhabdomyosarcoma

Apr 1, 2019 by in HEMATOLOGY Comments Off on Rhabdomyosarcoma

Chapter Outline PATHOLOGIC CLASSIFICATION OF RHABDOMYOSARCOMA RHABDOMYOSARCOMA IN CANCER PREDISPOSITION SYNDROMES GENETICS OF SPORADIC RHABDOMYOSARCOMA Gene Fusions Generated by Chromosomal Rearrangements Chromosome Copy Number Changes Amplification of Specific Chromosomal Regions…

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Pediatric Radiation Oncology

Apr 1, 2019 by in HEMATOLOGY Comments Off on Pediatric Radiation Oncology

Chapter Outline PRINCIPLES OF RADIATION ONCOLOGY THE PHYSICAL BASIS OF RADIOTHERAPY RADIOBIOLOGY Mechanisms of Radiation Damage Clonogenic Survival Curves The Oxygen Effect Radiation Interactions with Chemotherapeutic Agents TECHNOLOGICAL ADVANCES IN…

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Pediatric Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease

Apr 1, 2019 by in HEMATOLOGY Comments Off on Pediatric Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease

Chapter Outline ACUTE MYELOGENOUS LEUKEMIA Epidemiology and Etiology Biology Molecular Genetics Morphology and Cytochemistry Immunophenotype Cytogenetics Clinical Presentation Treatment Prognosis Minimal Residual Disease Relapsed or Refractory Disease ACUTE PROMYELOCYTIC LEUKEMIA…

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Retinoblastoma

Apr 1, 2019 by in HEMATOLOGY Comments Off on Retinoblastoma

Chapter Outline EPIDEMIOLOGY BIOLOGY OF RETINOBLASTOMA Cellular Origins of Retinoblastoma Retinoblastoma Tumor Cell Differentiation Retinoblastoma Genomics and Epigenomics Retinoblastoma Preclinical Models Retinoblastoma Translational Research GENETIC COUNSELING FOR FAMILIES WITH RETINOBLASTOMA…

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Immunotherapy of Cancer

Apr 1, 2019 by in HEMATOLOGY Comments Off on Immunotherapy of Cancer

Chapter Outline KEY COMPONENTS OF THE IMMUNE SYSTEM AND THEIR RELEVANCE IN CANCER IMMUNOTHERAPY Humoral Arm of the Immune System Cellular Arm of the Immune System TARGET ANTIGENS IN CANCER…

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Pediatric Renal Tumors

Apr 1, 2019 by in HEMATOLOGY Comments Off on Pediatric Renal Tumors

Chapter Outline PATHOLOGY OF PEDIATRIC RENAL TUMORS Staging Wilms Tumor (Nephroblastoma) Clear Cell Sarcoma of the Kidney Congenital Mesoblastic Nephroma Malignant Rhabdoid Tumor of the Kidney Renal Carcinomas in Children…

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Neuroblastoma

Apr 1, 2019 by in HEMATOLOGY Comments Off on Neuroblastoma

Chapter Outline EPIDEMIOLOGY PATHOGENESIS Embryology Development of the Sympathetic Nervous System Genetic Disorders Associated with Neuroblastoma Neuroblastoma Stem Cells Hereditary Predisposition to Neuroblastoma Genetic Aberrations in Sporadic Neuroblastoma Chromosomal Abnormalities…

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Hematologic Manifestations of Systemic Diseases

Apr 1, 2019 by in HEMATOLOGY Comments Off on Hematologic Manifestations of Systemic Diseases

Chapter Outline COLLAGEN DISORDERS Collagen Vascular Disease Vasculitis Connective Tissue Disorders INFECTIOUS DISEASES General Hematologic Signs of Infection Hematologic Aspects of Specific Infections CARDIAC DISEASE Hemolysis Acquired Coagulation Abnormalities Platelet…

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Cancer Chemotherapy for Pediatric Patients

Apr 1, 2019 by in HEMATOLOGY Comments Off on Cancer Chemotherapy for Pediatric Patients

Chapter Outline CHEMOTHERAPEUTIC AGENTS CLINICAL APPLICATION OF CHEMOTHERAPY CHEMOTHERAPY IN CHILDREN PHARMACOKINETIC CHANGES DURING CHILDHOOD Absorption Volume of Distribution Hepatic Metabolism Renal and Hepatic Excretion Influence of Underlying Disease on…

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Acute Lymphoblastic Leukemia

Apr 1, 2019 by in HEMATOLOGY Comments Off on Acute Lymphoblastic Leukemia

Chapter Outline CLASSIFICATION Morphologic and Cytochemical Classification Immunophenotype MOLECULAR PATHOGENESIS Transcriptional Regulators Growth Factor Signaling Molecular Pathogenesis of Select High-Risk Subtypes CLINICAL MANIFESTATIONS Peripheral Blood Bone Marrow Extramedullary Leukemia DIFFERENTIAL…

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