Investigation of Variant Haemoglobins and Thalassaemias

Mar 23, 2019 by in HEMATOLOGY Comments Off on Investigation of Variant Haemoglobins and Thalassaemias

Chapter Outline The haemoglobin molecule 283 Structural variants of haemoglobin 284 Haemoglobins with reduced solubility 284 Unstable haemoglobins 285 Haemoglobins with altered oxygen affinity 285 Haemoglobin M 285 Thalassaemia syndromes…

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Laboratory Organisation, Management and Safety

Mar 23, 2019 by in HEMATOLOGY Comments Off on Laboratory Organisation, Management and Safety

Chapter Contents Management structure and function 512 Staff appraisal 512 Continuing professional development 513 Strategic and business planning 513 Test reliability 515 Test selection 516 Test utility 516 Instrumentation 517…

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Investigation of a Thrombotic Tendency

Mar 23, 2019 by in HEMATOLOGY Comments Off on Investigation of a Thrombotic Tendency

Chapter Outline Introduction to thrombophilia 410 Pre-analytical factors 411 Tests for the presence of a lupus anticoagulant 411 Dilute Russell’s viper venom time 412 Platelet neutralisation test 413 Kaolin clotting…

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Diagnostic Radioisotopes in Haematology

Mar 23, 2019 by in HEMATOLOGY Comments Off on Diagnostic Radioisotopes in Haematology

Chapter Outline Sources of radioisotopes 352 Radiation protection 352 Apparatus for measuring radioactivity in vitro 353 Apparatus for measuring radioactivity in vivo 353 Measurement of radioactivity with a scintillation counter…

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Acquired Haemolytic Anaemias

Mar 23, 2019 by in HEMATOLOGY Comments Off on Acquired Haemolytic Anaemias

Chapter Outline Assessing the likelihood of acquired haemolytic anaemia 254 Assessment of the blood film and count in suspected acquired haemolytic anaemia 254 Immune haemolytic anaemias 255 Types of autoantibody…

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Molecular and Cytogenetic Analysis

Mar 23, 2019 by in HEMATOLOGY Comments Off on Molecular and Cytogenetic Analysis

Chapter Outline Methodologies 127 DNA extraction 127 Polymerase chain reaction 127 Amplification refractory mutation system (ARMS) 130 Gap-PCR 130 Fusion gene analysis 131 Restriction enzyme digestion 131 Allele-specific oligonucleotide hybridisation…

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Iron Deficiency Anaemia and Iron Overload

Mar 23, 2019 by in HEMATOLOGY Comments Off on Iron Deficiency Anaemia and Iron Overload

Chapter Outline Iron metabolism 166 Dietary iron absorption 166 Dietary and luminal factors 166 Iron absorption at the molecular level 167 Regulation of iron absorption 167 Cellular iron uptake and…

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