Fig. 1.1 Cancer incidence and mortality by site for both sexes (USA, 2015). The relative contributions of the major forms of cancer to overall cancer incidence and cancer-related mortality (both…
Fig. 40.1 Discovery of imatinib . Binding of imatinib occurs at the ATP-binding site as indicated by docking studies [28] and X-ray crystallography [29]. It has also been shown from…
Fig. 2.1 Chemical structures of DNA and RNA. The DNA within the eukaryotic nucleus is arranged in a double-stranded helix composed of two strands of opposing polarity. The helix is…
Fig. 13.1 Genetic heterogeneity of cancer cells. All cancer cells are derived from a common ancestor cell (black dot) that was subject to the pathogenic mutation (w). After an initial…
Fig. 35.1 MRI sequences of common primary brain tumors. (a) Sagittal T1-weighted and gadolinium-enhanced MR image showing a medulloblastoma in the posterior fossa (arrow) with compression of the pons and…
Fig. 3.1 Expression profiling schema. Above, schematic depiction of two-color hybridization on cDNA or oligonucleotide microarrays. RNA isolated from test and reference samples is labeled with two different fluors (here…
Fig. 22.1 Aldred Scott Warthin, M.D., Ph.D., (1866–1931) pioneer in hereditary cancer research. Fig. 22.2 Pedigree family G . This family was described in the first published systematic evaluation of…
Fig. 38.1 Molecular therapies with targets associated with the hallmarks of cancer . The inner yellow circle shows the hallmarks of cancer as defined by Hanahan and Weinberg. The middle…
Estimated new cases Estimated deaths Both genders Male Female Both genders Male Female All sites 1,665,540 855,220 810,320 585,720 310,010 275,710 Oral cavity and pharynx 42,440 30,220 12,220 8390…
Fig. 43.1 Immunohistochemical staining for the estrogen receptor (ER) in breast cancer. The ER is detected as a brown color in the nucleus of the tumor cells (arrows). Fig. 43.2…
