Pulmonary Complications
Fig. 22.1 Diffuse ground glass opacities in diffuse alveolar hemorrhage, confirmed by BAL. BAL bronchoalveolar lavage b. Pulmonary function tests (PFTs) show increased DLCO; however, often these patients cannot…
Infectious Complications
Fig. 17.1 Phases of opportunistic infections among allogeneic HSCT recipients. EBV Epstein–Barr virus, HHV-6 human herpes virus 6, PTLD posttransplant lymphoproliferative disease . © Granted by Elsevier a. Viral infections: Herpes…
Acute Graft-Versus-Host Disease (GVHD)
Organ Clinical manifestations Histologic findings Alternate diagnoses Skin Erythematous maculopapular rash involving the palms, soles, pinnae, spreading to the trunk and later extremities. +/− pruritis. Bullae/desquamation in severe cases Basal…
Long-Term Follow-Up and Survivorship
NCI office of Cancer Survivorship http://cancercontrol.cancer.gov/ocs/ LiveStrong™ Foundation http://www.livestrong.org National Marrow Donor Program http://www.bethematch.org National Bone Marrow Transplant Link http://www.nbmtlink.org HSCT survivors are faced with a significantly increased risk for…
Palliative Care
Antiemetic agent Action Dosage Side effects Anticholinergics/ antimuscarinics A direct depressant action on the VC. An antispasmodic action on the gut. Useful for motion sickness and post-operative N/V (PONV) Hyoscine…
Posttransplant Relapse
© Springer Science+Business Media, LLC 2015Richard T. Maziarz and Susan Schubach Slater (eds.)Blood and Marrow Transplant Handbook10.1007/978-3-319-13832-9_32 32. Posttransplant Relapse Marlise R. Luskin1 and David L. Porter1 (1) Division of Hematology/Oncology and the Abramson Cancer Center, Perelman…
Graft Failure
Type of product TNC/kg body weight of recipient CD34 + cell/kg body weight of recipient Bone marrow > 2 × 108 Peripheral blood stem cells > 2 × 108 > 3 × 106 Double cord blood—each unit > 2 × 107 …
Secondary Malignancies
Alkylating agents Topoisomerase II inhibitors Latency 3–8 years 2–3 years Incidence 2–20 % 2–12 % Myelodysplastic phase Present Absent FAB type M1, M2 M4, M5 Cytogenetics 5-, 7-, 5q-, 7q- 11q23…
Psychiatric Complications
Patient condition Suggested antidepressant drug of choice Depression with anxiety or agitation Paroxetine (Paxil®) Depression with lethargy and amotivation Fluoxetine (Prozac®), buproprion (Wellbutrin®), or venlafaxine (Effexor®) Preexisting cardiac disease Congestive…
Women’s Hormonal Health Issues
Composition Product name FDA-approved dosage Vaginal creams 17β-estradiol Estrace vaginal cream® Initial: 2–4 g/day for 1–2 weeks maintenance: 1 g/1–3 times/week Conjugated estrogens Premarin vaginal cream® For VVA: 0.5–2 g/day for 21 day…
