5-LOX, 5-Lipoxygenase; CDK, cyclin-dependent kinase; DFMO, difluoromethylornithine; EGFR, epidermal growth factor receptor; ER, estrogen receptor; FGFR, fibroblast growth factor receptor; HIF-1α, hypoxia-inducible factor-1 alpha; IGF-1R, insulin-like growth factor-1 receptor; MEK,…
t(1:13)(p36;q14) PAX3-FOXO1A PAX7-FOXO1A Alveolar soft-part sarcoma t(X;17)(p11;q25) TFE3-ASPL Angiomatoid fibrous histiocytoma t(12;16)(q13;p11) CREB1-EWSR1 ATF1-FUS Clear cell sarcoma t(12;22)(q13;q12) ATF1-EWSR1 CREB1-EWSR1 Dermatofibrosarcoma protuberans t(17;22)(q22;q13) PDGFB- COL1A1 Desmoplastic small round cell tumor…
Figure 24-1 Schematic illustrations of the types of genome aberrations found in human cancers. 18 Table 24-1 Cancer Gene Census Summary Aberration Type Number of Aberrations Examples of Prominent Affected…
Figure 26-1 Kaplan-Meier analysis of overall survival in 2628 children with newly diagnosed acute lymphocytic leukemia (ALL). The patients participated in 15 consecutive studies conducted at St. Jude Children’s Research…
Figure 20-1 Genomic alterations in glioma co-segregate with only some of the identified molecular subtypes. (With permission from Verhaak RG, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies…
Figure 5-1 Chromatin surrounding an actively expressed gene in a normal mature cell versus surrounding that same gene when it is DNA hypermethylated and aberrantly, heritably, silenced in a tumor…
Figure 43-1 Schematic illustration of the key intracellular signaling pathways involved in the pathogenesis of differentiated thyroid carcinoma. Figure 43-2 Schematic illustration of the key intracellular signaling pathways involved in…
In addition to these highly penetrant hereditary syndromes, genome-wide association studies are identifying new loci that confer increased risk for either BCC or SCC, although the mechanistic details remain. Single-nucleotide…
Figure 30-1 An outline of the main factors leading from multiple myeloma (MM) to monoclonal gammopathy of undetermined significance (MGUS); the distinction between HD and NHD MM; and finally additional…
Figure 33-1 The Field Cancerization Theory is defined as the presence of one or more mucosal areas consisting of epithelial cells with cancer-associated genetic or epigenetic alterations. A precursor field…
