FIGURE 35-1. Structure of proglucagon and the proglucagon-derived peptides. The amino acid sequences of glucagon, glucagon-like peptide (GLP)-1, and GLP-2 are shown, as well as the cleavage site for dipeptidyl…
FIGURE 3-1. Schematic diagram of the anterograde secretory pathway in a peptide hormone–secreting endocrine cell. Secretory proteins synthesized in the endoplasmic reticulum (ER) are transported to and through Golgi stacks…
Neonatal diabetes is rare and may be transient or permanent.37 Several genetic defects have been identified in these patients, most notably mutations in the adenosine triphosphate (ATP)-sensitive potassium channel (KATP)…
FIGURE 12-1. Schematic representation of lateral brain section demonstrating hypothalamic nuclei. Dashed lines represent the frontal (coronal) section planes illustrated in Figures 12-2 and 12-3. 1, preoptic nucleus; 2, paraventricular…
FIGURE 30-1. Extreme cachexia in an anorexia nervosa patient. (From Bliss EL, Branch CHH: Anorexia Nervosa: Its History, Psychology, and Biology. New York: Paul B. Hoeber, 1960.) A corollary of…
FIGURE 2-1. Chemical structure of DNA and its relationship to chromatin. The most basic unit of the chromosome is DNA, which is composed of polynucleotide chains made up of four…
Possible mechanisms by which pancreatic cancer could contribute to the development of type 2 diabetes include the following: (1) destruction of islets, (2) impairment of the insulin secretory mechanism, (3)…
FIGURE 29-1. A, Clinical response to leptin therapy in congenital leptin deficiency. B, Leptin therapy is associated with pulsatile gonadotropin secretion at an appropriate developmental age in child A (age…
FIGURE 38-1. Congenital lipodystrophy. Although there is a lack of consensus on the definition of the lipodystrophy syndrome(s), the diagnosis of lipodystrophy is usually made clinically and is often based…
