Overview of the Clinical Manifestations of Hypothyroidism Michael T. McDermott Introduction Hypothyroidism is a disorder in which the thyroid gland is unable to synthesize and secrete sufficient amounts of thyroid…
Central Hypothyroidism Luca Persani Paolo Beck-Peccoz Introduction Central hypothyroidism (CH) is a rare disease characterized by a defect of thyroid hormone production due to an insufficient stimulation by thyrotropin (TSH)…
Primary Hypothyroidism Due to Other Causes Peter A. Singer Table 37.1 Other Causes of Primary Hypothyroidism Thyroid ablation Radioactive iodine therapy or surgery for Graves’ thyrotoxicosis Toxic nodular goiter Nontoxic nodular goiter External radiotherapy…
Genetic Defects Causing Hypothyroidism Thomas Vulsma Jan J.M. De vijlder Congenital hypothyroidism (CH), a lack of thyroid hormone (TH) already present at birth, is a relatively common medical condition with…
Chronic Autoimmune Thyroiditis Anthony P. Weetman Chronic autoimmune thyroiditis is the original paradigm for autoimmune diseases in general. Only foreign proteins were considered to be antigens until Witebsky and Rose…
Introduction to Hypothyroidism Lewis E. Braverman David S. Cooper Hypothyroidism is the most common clinical disorder of thyroid function. It is most often caused by a disorder of the thyroid…
Subclinical Thyrotoxicosis Douglas S. Ross The introduction of serum thyrotropin (TSH) measurements into clinical practice during the early 1970s provided the necessary tool for defining subclinical hypothyroidism, although it took…
Treatment of Thyrotoxicosis David S. Cooper The ideal treatment of thyrotoxicosis would be directed at its cause. This is possible in only a few patients; e.g., those with exogenous thyrotoxicosis…
Diagnosis of Thyrotoxicosis Paul W. Ladenson Thyrotoxicosis often presents as a distinctive clinical syndrome readily confirmed by the findings of a low serum thyrotropin thyroid-stimulating hormone (TSH) concentration and high…
Thyrotoxic Storm Leonard Wartofsky Thyrotoxic storm or crisis is a rare, life-threatening syndrome characterized by exaggerated clinical manifestations of thyrotoxicosis (1). Its incidence is not precisely known because there are…
