Antimicrotubule Agents Christopher J. Hoimes Lyndsay N. Harris MICROTUBULES Microtubules are vital and dynamic cytoskeletal polymers that play a critical role in cell division, signaling, vesicle transport, shape, and polarity,…
Topoisomerase Interactive Agents Khanh T. Do Shivaani Kummar James H. Doroshow Yves Pommier CLASSIFICATION, BIOCHEMICAL, AND BIOLOGIC FUNCTIONS OF TOPOISOMERASES Nucleic acids (DNA and RNA) being long polymers, topoisomerases fulfill…
Antimetabolites M. Wasif Saif Edward Chu ANTIFOLATES Reduced folates play a key role in one-carbon metabolism, and they are essential for the biosynthesis of purines, thymidylate, and protein biosynthesis. Aminopterin…
Platinum Analogs Peter J. O’Dwyer A. Hilary Calvert INTRODUCTION The platinum drugs represent a unique and important class of antitumor compounds. Alone or in combination with other chemotherapeutic agents, cis-diamminedichloroplatinum…
Alkylating Agents Kenneth D. Tew PERSPECTIVES Alkylating agents were the first anticancer molecules developed, and they are still used today. After more than 50 years of use, the basic chemistry…
Pharmacogenomics Christine M. Walko Howard L. McLeod INTRODUCTION The evolution of understanding cancer biology has yielded many advances that have been translated into cancer treatment. Application of this knowledge has…
Pharmacokinetics and Pharmacodynamics of Anticancer Drugs Alex Sparreboom Sharyn D. Baker INTRODUCTION Drug selection and therapy considerations in oncology were originally solely based on observations of the effects produced.1 To…
Cancer Immunotherapy Steven A. Rosenberg Paul F. Robbins Giao Q. Phan Steven A. Feldman James N. Kochenderfer INTRODUCTION Progress in understanding basic aspects of cellular immunology and tumor-host immune interactions…
Essentials of Radiation Therapy Meredith A. Morgan Randall K. Ten Haken Theodore S. Lawrence INTRODUCTION The beneficial use of radiation was launched by the experiments of Wilhelm Roentgen, who, in…
Trends in United States Cancer Mortality Tim E. Byers INTRODUCTION Cancer incidence registries now cover nearly all of the US population. State-based vital records systems and aggregate national systems regularly…
