Rare Inherited Coagulation Disorders Other than Hemophilia Pier Mannuccio Mannucci Flora Peyvandi Massimo Franchini The rare inherited coagulation disorders (RICDs), usually transmitted in an autosomal recessive fashion, represent 3% to…
von Willebrand Disease: Diagnosis, Classification, and Treatment J. Evan Sadler David Lillicrap von Willebrand disease (vWD) was discovered by Erik von Willebrand,1,2 a Finnish internist who investigated a family living…
Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia Edward G.D. Tuddenham Peter W. Collins T. T. Yee HISTORICAL INTRODUCTION Knowledge of a congenital bleeding disorder affecting male infants can…
Differential Diagnosis of the Bleeding Patient Jill M. Johnsen Barbara A. Konkle The hematologist is often faced with the question of whether a patient has an underlying bleeding disorder. This…
Overview of Inherited Hemorrhagic Disorders Gilbert C. White II Harold R. Roberts Victor J. Marder The focus in Section A of Part III of this book is on inherited hemorrhagic…
Laboratory Markers of Endothelial Cell Activation and Dysfunction Eduard Shantsila Gregory Y.H. Lip Robert P. Hebbel The diverse functions of the vascular endothelium are of critical importance in maintaining physiologic…
Leukocyte Function and Contribution to Disease Edith Van De Vijver Taco W. Kuijpers Inflammation is a tightly regulated process initiated after tissue injury or infection. The main function of inflammation…
Endothelial Cell-Blood Cell Interactions Klaus Ley Interactions between monocytes, platelets, and endothelial cells are intimately involved with and are of key importance for the regulation of hemostasis, thrombosis, inflammation, and…
Heparin and Vascular Proteoglycans Douglas M. Tollefsen Lijuan Zhang Heparin is a sulfated glycosaminoglycan isolated from mammalian tissues that are rich in mast cells. When administered intravenously, heparin binds to…
Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway Wolfram Ruf Tissue and vascular injury requires a rapid hemostatic response that is critically dependent on the tissue factor (TF)-initiated extrinsic coagulation pathway….
