Intracranial Hemorrhage and Subarachnoid Hemorrhage Timolaos Rizos Thorsten Steiner INTRACEREBRAL HEMORRHAGE Epidemiology, Risk Factors and Prognosis Intracerebral hemorrhage (ICH) is an extravasation of blood into the brain parenchyma. Hemorrhagic stroke…
Aneurysms (Large and Small Arteries) Carlos E. Sanchez Sangita Kapur Neal L. Weintraub Aneurysms of the aorta and its branch vessels are a major health care concern; more than 15,000…
Arteriovenous Malformations and Hemangiomas and Cerebral Cavernous Malformations Kevin J. Whitehead Douglas A. Marchuk Mark L. Kahn The cardiovascular system is organized into a hierarchical, branching arrangement by which blood…
Hereditary Hemorrhagic Telangiectasia Michelle Letarte Claire L. Shovlin Hereditary hemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, was first recognized as a genetic disorder in the 19th century. HHT is…
Disorders of Connective Tissue and Extracellular Matrix Fransiska Malfait Anne De Paepe THE CONNECTIVE TISSUE AND THE EXTRACELLULAR MATRIX The connective tissue is the most abundant tissue throughout the body…
Overview of Primary Disorders of Blood Vessels William C. Aird The cardiovascular system consists of a closed system or arteries, arterioles, capillaries, venules, and veins, in addition to an open…
Laboratory Markers of Platelet Activation Paul Harrison Alan D. Michelson Prevention of platelet activation in the intact circulation is normally controlled by the antithrombotic nature of the endothelial cell surface,…
Acquired Disorders of Platelet Function A. Koneti Rao Joel S. Bennett Platelets are essential for normal hemostasis. Thus, defects in platelet function may lead to bleeding diatheses. Platelet function defects…
Inherited Disorders of Platelet Function Joel S. Bennett A. Koneti Rao Prolongation of the bleeding time in a patient with a normal platelet count suggests the presence of either von…
Acquired Nonimmune Thrombocytopenia Andreas Greinacher Theodore E. Warkentin Acquired thrombocytopenic disorders can be divided into five categories, plus the spurious entity of pseudothrombocytopenia (Table 64.1): hemodilution, sequestration (usually due to…
