Mechanical Devices and Embolectomy HervÉ Decousus Patrick Mismetti Nicolas Meneveau VENA CAVA FILTERS AND VENOUS THROMBOEMBOLISM Interruption of the vena cava by filter insertion was initially suggested by Armand Trousseau…
Anticoagulant and Procoagulant Proteins in the Animal Kingdom Angelina Wei Ling Tan Shiyang Kwong R. Manjunatha Kini Blood circulation has a crucial role in the survival of vertebrate animals, including…
Foundations of Thrombolytic Therapy Victor J. Marder Daphne B. Stewart Thrombolytic therapy represents a conjoint approach to vascular reperfusion, based primarily on the use of fibrinolytic agents delivered systemically or…
Antiplatelet Therapy Carlo Patrono As reviewed in other chapters, platelet activation and aggregation play a key role in atherothrombosis.1 Antiplatelet drugs target enzymes or receptors involved in the platelet synthesis…
New Antithrombotic Drugs Jeffrey I. Weitz Peter L. Gross Currently available antithrombotic drugs include (a) antiplatelet agents, which inhibit platelet activation or aggregation, (b) anticoagulants, which attenuate fibrin formation, and…
Coumarin-Induced Skin Necrosis and Venous Limb Gangrene Theodore E. Warkentin Thrombotic events that result from coumarin administration are incongruous but well-documented complications of anticoagulant therapy. The key role of coumarin…
Hemorrhagic Complications of Anticoagulation Sam Schulman Mark A. Crowther Bleeding is the most common complication of anticoagulant therapy. The spectrum is from seemingly harmless subcutaneous ecchymoses, albeit cosmetically disturbing for…
Vitamin K Antagonists: Biochemistry, Pharmacology, and Management Nirmish Shah Thomas L. Ortel Sam Schulman INTRODUCTION/HISTORY Vitamin K antagonists (VKAs) are currently the most common oral anticoagulants used worldwide. The discovery…
Pharmacology and Mode of Action of Heparin and Glycosaminoglycans Meyer Michel Samama Jeanine M. Walenga Evi Kalodiki Jawed Fareed Heparin belongs to a class of linear acidic polysaccharides known as…
Overview of Therapeutic Agents Used in Thrombotic Disorders Sam Schulman Victor J. Marder In this section, the many recent developments in drug and device therapy for venous or arterial thromboembolism…
