Platelet Morphology, Biochemistry, and Function
SUMMARY Print Section Listen SUMMARY The approximately 1 trillion platelets that circulate in an adult human are small anucleate cell fragments adapted to adhere to damaged blood vessels, to aggregate…
The Vascular Purpuras
SUMMARY Print Section Listen SUMMARY Purpura, the clinical manifestation of blood extravasation into mucosa or skin, results from various conditions, including rheumatologic, infectious, dermatologic, traumatic, and hematologic disorders. This chapter…
Atherothrombosis: Disease Initiation, Progression, and Treatment
SUMMARY Print Section Listen SUMMARY The consequences of atherosclerotic vascular disease are the leading cause of morbidity and mortality in the developed countries of the world and are rapidly approaching…
Hemophilia A And Hemophilia B
SUMMARY Print Section Listen SUMMARY Hemophilias A and B are the only two bleeding disorders inherited in a sex-linked fashion. The gene for both disorders is on the long arm…
Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis
SUMMARY Print Section Listen SUMMARY The coagulation cascade consists of a complex network of reactions that are essential for the conversion of zymogens into enzymes and of inactive procofactors into…
Disseminated Intravascular Coagulation
SUMMARY Print Section Listen SUMMARY When procoagulants are produced or introduced into the blood and overcome the anticoagulant mechanisms of coagulation, intravascular thrombin is generated systemically, which can lead to…
Venous Thrombosis
SUMMARY Print Section Listen SUMMARY Venous thromboembolism, consisting of deep vein thrombosis and/or pulmonary embolism, is a common disorder with an estimated 900,000 patients each year in the United States…
Fibrinolysis and Thrombolysis
SUMMARY Print Section Listen SUMMARY Improved understanding of the molecular mechanisms of fibrinolysis has led to major advances in fibrinolytic and antifibrinolytic therapy. Characterization of the genes for all the…
The Antiphospholipid Syndrome
SUMMARY Print Section Listen SUMMARY The antiphospholipid (aPL) syndrome (APS) is an acquired thrombophilic disorder in which patients have vascular thrombosis and/or pregnancy complications attributable to placental insufficiency, accompanied by…
Thrombotic Microangiopathies
SUMMARY Print Section Listen SUMMARY Thrombotic microangiopathy is a general term for the combination of microangiopathic hemolytic anemia and thrombocytopenia, often accompanied by signs and symptoms consistent with disseminated microvascular…
