Pattern and risk factors of local recurrence and intravesical recurrence after segmental ureterectomy for upper tract urothelial carcinoma

May 11, 2025 by in ONCOLOGY Comments Off on Pattern and risk factors of local recurrence and intravesical recurrence after segmental ureterectomy for upper tract urothelial carcinoma

Highlights • Segmental ureterectomy was feasible for selected ureteral cancer patients. • Segmental ureterectomy faced a considerable risk of local recurrence and intravesical recurrence. • G3 and lymphatic vascular infiltration…

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Real-world treatment patterns and outcomes of patients with unresectable or metastatic urothelial carcinoma receiving systemic therapy in Japan

May 11, 2025 by in ONCOLOGY Comments Off on Real-world treatment patterns and outcomes of patients with unresectable or metastatic urothelial carcinoma receiving systemic therapy in Japan

Highlights • A study in patients with unresectable or metastatic urothelial carcinoma (mUC). • Half of patients received cisplatin-based regimens as first-line therapy. • After 2017, 58.2% of patients received…

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Bempegaldesleukin plus nivolumab in first-line advanced/metastatic urothelial carcinoma: Results from a phase II single-arm study (PIVOT-10)

May 11, 2025 by in ONCOLOGY Comments Off on Bempegaldesleukin plus nivolumab in first-line advanced/metastatic urothelial carcinoma: Results from a phase II single-arm study (PIVOT-10)

Highlights • Bempegaldesleukin is a pegylated interleukin-2 cytokine. • This phase 2 study was conducted in patients previously untreated advanced or metastatic urothelial carcinoma and low PD-L1 expression. • The…

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Guidelines versus real-world data in metastatic bladder cancer: A population-based study on first-line chemotherapy treatment patterns

May 11, 2025 by in ONCOLOGY Comments Off on Guidelines versus real-world data in metastatic bladder cancer: A population-based study on first-line chemotherapy treatment patterns

Abstract Background For patients with metastatic bladder cancer (mBC) palliative chemotherapy is one of the main treatment options. Real-world insights into outcomes are available, but a comprehensive overview of specific…

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Critical care therapy and in-hospital mortality after radical nephroureterectomy for nonmetastatic upper urinary tract carcinoma

May 11, 2025 by in ONCOLOGY Comments Off on Critical care therapy and in-hospital mortality after radical nephroureterectomy for nonmetastatic upper urinary tract carcinoma

Highlights • Critical care therapy represents a 5- to 6-fold multiple of in-hospital mortality rate. Moreover, critical care therapy very closely reflects in-hospital mortality rate changes that occurred over time…

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Is ipsilateral systematic biopsy combined with targeted biopsy the optimal substitute for bilateral systematic biopsy combined with targeted biopsy: A systematic review and meta-analysis

May 11, 2025 by in ONCOLOGY Comments Off on Is ipsilateral systematic biopsy combined with targeted biopsy the optimal substitute for bilateral systematic biopsy combined with targeted biopsy: A systematic review and meta-analysis

Highlights • The standard prostate biopsy method results in overdiagnosis and overtreatment. • ips-SB+TB can be an alternative for detecting prostate cancer (PCa). • Ips-SB+TB has comparable efficiency in detecting…

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“I was in a very deep, dark place… I wasn’t prepared for that”: A qualitative assessment of the emotional well-being needs of patients undergoing cystectomy

May 11, 2025 by in ONCOLOGY Comments Off on “I was in a very deep, dark place… I wasn’t prepared for that”: A qualitative assessment of the emotional well-being needs of patients undergoing cystectomy

Highlights • Patients undergoing cystectomy have significant emotional and mental health needs. • Providers should proactively address the mental health needs of these patients. • Mental health specialists should be…

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The efficacy of adjuvant mitotane therapy and radiotherapy following adrenalectomy in patients with adrenocortical carcinoma: A systematic review and meta-analysis

May 11, 2025 by in ONCOLOGY Comments Off on The efficacy of adjuvant mitotane therapy and radiotherapy following adrenalectomy in patients with adrenocortical carcinoma: A systematic review and meta-analysis

Highlights • This is the first systematic review and meta-analysis, including randomized controlled trials, to investigate the oncological outcomes of adjuvant therapy after radical adrenalectomy in patients with adrenocortical carcinoma….

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Development of TAR-200: A novel targeted releasing system designed to provide sustained delivery of gemcitabine for patients with bladder cancer

May 11, 2025 by in ONCOLOGY Comments Off on Development of TAR-200: A novel targeted releasing system designed to provide sustained delivery of gemcitabine for patients with bladder cancer

Highlights • Development of novel therapies is needed for patients with high-risk bladder cancer. • TAR-200 is a gemcitabine intravesical releasing system designed for bladder cancer. • TAR-200 was well…

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