The role of intravesical chemotherapy following nephroureterectomy in upper tract urothelial carcinoma: A systematic review and meta-analysis

May 11, 2025 by in ONCOLOGY Comments Off on The role of intravesical chemotherapy following nephroureterectomy in upper tract urothelial carcinoma: A systematic review and meta-analysis

Highlights • Intravesical chemotherapy significantly reduces intravesical recurrence risk after NUT at 12 (OR 0.46) and 24 months (OR 0.41). • No statistically significant difference was found between single intra…

read more

Assessing the causal relationship between gut microbiota and prostate cancer: A two-sample Mendelian randomization study

May 11, 2025 by in ONCOLOGY Comments Off on Assessing the causal relationship between gut microbiota and prostate cancer: A two-sample Mendelian randomization study

Highlights • Identified 12 gut microbial taxa potentially linked to prostate cancer risk using MR analysis. • Employed robust statistical methods to ensure reliability of causal inference results. • Explored…

read more

Concomitant antihistamine administration is associated with improved survival outcomes in patients with locally advanced or metastatic urothelial carcinoma treated with atezolizumab. Analysis of individual participant data from IMvigor210 and IMvigor211

May 11, 2025 by in ONCOLOGY Comments Off on Concomitant antihistamine administration is associated with improved survival outcomes in patients with locally advanced or metastatic urothelial carcinoma treated with atezolizumab. Analysis of individual participant data from IMvigor210 and IMvigor211

Highlights • In preclinical studies, it has been demonstrated that antihistamines may reverse macrophage immunosuppression, reactivate t-cell cytotoxicity, and enhance the immunotherapy response. • By use of individual patient data…

read more

Real-world survival and economic burden among patients with locally advanced or metastatic urothelial carcinoma in the United States

May 11, 2025 by in ONCOLOGY Comments Off on Real-world survival and economic burden among patients with locally advanced or metastatic urothelial carcinoma in the United States

Highlights • Real-world study of US adults with la/mUC receiving first-line therapy. • Most received platinum-based chemotherapy (48.2%) or PD-1/L1 inhibitor (35.5%). • All first-line therapies had short survival, high…

read more

Adjuvant immunotherapy in high-risk muscle invasive urothelial carcinoma: A systematic review and meta-analysis of randomized clinical trials

May 11, 2025 by in ONCOLOGY Comments Off on Adjuvant immunotherapy in high-risk muscle invasive urothelial carcinoma: A systematic review and meta-analysis of randomized clinical trials

Highlights • Initial trial results examining the efficacy of adjuvant immune checkpoint inhibitors in the setting of high-risk, resected muscle invasive urothelial carcinoma provided disparate results. • In this systematic…

read more

Impact of smoking exposure on disease progression in high risk and very high-risk nonmuscle invasive bladder cancer patients undergoing BCG therapy

May 11, 2025 by in ONCOLOGY Comments Off on Impact of smoking exposure on disease progression in high risk and very high-risk nonmuscle invasive bladder cancer patients undergoing BCG therapy

Highlights • High grade and very high grade NMIBC has the potential to reoccur and progress and the BCG intravesical therapy is an adjuvant gold standard treatment. • Smoking impacts…

read more

Bladder cancer associated with elevated heavy metals: Investigation of probable carcinogenic pathways through mitochondrial dysfunction, oxidative stress and mitogen-activated protein kinase

May 11, 2025 by in ONCOLOGY Comments Off on Bladder cancer associated with elevated heavy metals: Investigation of probable carcinogenic pathways through mitochondrial dysfunction, oxidative stress and mitogen-activated protein kinase

Highlights • The carcinogenic pathways of heavy metals/ trace elements in bladder cancer are studied. • They include alterations in MD, OS/ROS, and p38-MAPK pathway. • This data provides a…

read more
Get Clinical Tree app for offline access