Oncohema Key

Recommendation Grade Comments Reference Data from studies of non-oncology patientsa Data from studies of adult oncology patientsa Data from studies of pediatric oncology patientsa Antibacterial prophylaxis with a fluoroquinolone should…

Organ RT side effect Treatment Level of evidenceb Hematologic Neutropenia Consider G-CSF (see Chap.​ 15 for more detail) 1C Thrombocytopenia Platelet transfusion 1C Anemia Red blood cell transfusion; erythropoietin (EPO)-stimulating…

Malnutrition or evidence of cachexia present at diagnosis Highly emetogenic chemotherapeutic regimens Treatment regimens associated with severe GI complications such as constipation, diarrhea, loss of appetite, mucositis, enterocolitis (i.e., treatment…

High risk (>90 % frequency of emesis in the absence of prophylaxis) Altretamine bCytarabine 3 g/m2/dose Procarbazine (oral) bCarboplatin Dacarbazine Streptozocin Carmustine >250 mg/m2 bDactinomycin bThiotepa ≥300 mg/m2 bCisplatin Mechlorethamine bCyclophosphamide…

Clinical scenario Recommendations Level of evidenceb Primary thromboprophylaxis Not recommended (including LMWH, warfarin, FFP) 1B Routine screening with coagulation studies or for thrombophilia not recommended 2C Thrombophilia screening can be…

Disease Potential side effect Treatment Level of evidenceb Acute lymphoblastic leukemia Leukostasis Rapid initiation of chemotherapy 1A Hyperhydration 1C Consider leukapheresis for WBC >400–600 × 109/L if no delay in antileukemic chemotherapy…

Laboratory tumor lysis syndrome (2 or more of the following occurring from 3 days prior up to 7 days after commencement of cytotoxic therapy)  Uric acid ≥8 mg/dL or 25…

Clinical status Description Hemoglobin level for transfusion (g/dL) Level of evidencea Stable Asymptomatic, imminent marrow recovery <7 1C Vital sign changes Tachycardia, tachypnea, hypotension <8 1C Thrombocytopenia Recent or active…