Recommendation Level of evidencea Insertion Hand hygiene with soap and water or waterless alcohol gel 1A Maximal sterile barrier precautions: cap, mask, sterile gown, sterile gloves, sterile full body…
Therapy-related risk factors Chemotherapy and biotherapy agents Antimetabolites Cytarabine 5-fluorouracil Methotrexate Antitumor antibiotics Actinomycin D Amsacrine Mithramycin Mitomycin Alkylating agents Busulfan Cyclophosphamide Mechlorethamine Procarbazine Thiotepa Anthracyclines Daunorubicin Doxorubicin Epirubicin Taxanes…
Fig. 9.1 Pain assessment tools. (a) FLACC behavioral pain assessment scale. (b) Wong-Baker faces pain scale. (c) Visual analog scale (VAS) The perception of pain is directly related to a…
Clinical scenario Recommendations Level of evidenceb Spinal cord compression Corticosteroids: decadron 1–2 mg/kg (max 10 mg) followed by 0.25–0.5 mg/kg (max 4 mg) Q6h—may complicate ability to make a diagnosis…
Clinical scenario Recommendation Level of evidencea Risk stratification Must be individualized at local institutions due to lack of evidence to support the needs of each individual treatment area 2C Baseline…
© Springer Berlin Heidelberg 2015James H. Feusner, Caroline A. Hastings and Anurag K. Agrawal (eds.)Supportive Care in Pediatric OncologyPediatric Oncology10.1007/978-3-662-44317-0_18 18. Knowledge Gaps and Opportunities for Research Anurag K. Agrawal1 , Caroline A. Hastings1 and James H. Feusner1 (1) Department of Hematology/Oncology, Children’s…
Prior to chemotherapyb During chemotherapyc After chemotherapy completionc, d Diphtheria-tetanus-acellular pertussis Continuation of primary series during lower-intensity phases of therapy (i.e., ALL in maintenance) Continuation of primary series; booster…
Clinical scenario Recommendation Level of evidenceb Treatment of myelosuppression after chemotherapy (primary prophylaxis) Consider if risk of neutropenia is ≥20 % or if patient had neutropenia with previous course of…
Clinical scenario Recommendations Level of evidencea SVCS/SMS Elevate head of the bed 1C Place all IV lines in lower extremities 2C Consider use of loop diuretics 2C Remove indwelling catheter…
Treatment modality Potential side effects Chemotherapy Bacterial overgrowth Bile acid malabsorption Pancreatic insufficiency Neutropenic enterocolitis Edema, ulceration, atrophy Increased bowel permeability Transmural infection Radiation therapy Radiation enteritis Stricture Inflammation/cell death…
