Conserved catalytic domain Activity Localization Principal targets under stress Regulation by CR/ROS Sirtuin function References Deacetylase Nucleus/cytoplasm H4K9Ac, H4K16Ac, SUV39h1, XPA, XPC, NBS1, hMOF, TIP60, WRN, Ku70, Rb, FOXO, HIF-1α,…
Fig. 16.1 Three-dimensional structure of VDAC1 and its channel activity. (A), VDAC1 monomer and dimer structures: (a) Side view of the crystal structure of VDAC1 (PDB code: 3EMN). The β-barrel…
Fig. 2.1 Synthetic lethality. (a) Idealized DNA repair pathways in a normal cell that process a specific DNA lesion, with primary and secondary pathways catalyzed by enzymes 1–3 or a–c,…
Fig. 18.1 The pro-inflammatory/suppressive phenotype of TERS-imprinted myeloid cells. The characteristics of TERS-imprinted bone marrow-derived macrophages (middle) are compared with those of canonical characteristics of M1 (left) and M2 (right)…
Fig. 3.1 The cell cycle and its checkpoints. Cyclins are individually synthesised and degraded in a phase distinctive manner and bind and activate specific Cdks which coordinates the sequential progression…
Fig. 4.1 The central part of the figure represents the p53 protein indicating its main domains: the N-terminal transactivation domain, the proline-rich domain, a central DNA binding core and a…
Fig. 10.1 Overexpression of HSP70 affects multiple cancer-relevant pathways. (a) HSP70 inhibits the extrinsic apoptosis pathway by binding to the death receptors DR4 and DR5, and preventing the formation of…
Fig. 6.1 A brief history of microRNA research milestone The function of miRNAs requires a sequence specific match to their target mRNA. The majority of match pairs are composed of…
Fig. 15.1 Schematic showing the link between cellular stress and glycolysis. Stress stimuli trigger the stress signaling pathway such as p38/MAPK resulting in the activation of MAPK-M2 by phosphorylation. MAPK-M2…
Fig. 17.1 Evolution of inflammation in pancreatic ductal adenocarcinoma (PDAC). Progression through pre-invasive pan-IN stages to PDAC is associated with loss of cell mediated immunity, decreased numbers of dendritic cells…
