Classification, Use, and Toxicity of Clinically useful Chemotherapy and molecular Targeted Therapy Anis Toumeh Roland T. Skeel I. CLASSES OF DRUGS Chemotherapeutic agents, whether classical or molecular targeted, are customarily…
Side Effects of Immune Therapy John E. Janik I. INTRODUCTION The toxicity profile of immune-based therapies has in the past typically been related to the dose and schedule of the…
Side Effects of Chemotherapy Janelle M. Tipton I. INTRODUCTION Supportive care of the patient receiving chemotherapy continues to gain recognition as an equally important component of definitive therapy. Advances have…
Metastatic Cancer of Unknown Origin Christophe Massard I. INTRODUCTION Carcinomas of unknown primary site (CUP) are a group of heterogeneous tumors that share the unique clinical characteristic of metastatic diseases…
Multiple Myeloma, Other Plasma Cell Disorders, and Primary Amyloidosis Rachid Baz Mohamad A. Hussein I. INTRODUCTION A. Types of plasma cell dyscrasias Plasma cell dyscrasias represent a heterogeneous group of…
Non-Hodgkin Lymphoma Catherine Lai Mark Roschewski Wyndham H. Wilson I. INTRODUCTION Non-Hodgkin lymphomas (NHLs) are a diverse group of malignant neoplasms involving lymphocytes of B-cell, T-cell, or natural killer (NK)-cell…
Hodgkin Lymphoma Shruti Chaturvedi David S. Morgan I. INTRODUCTION Hodgkin lymphoma (HL) is an uncommon lymphoproliferative malignancy with approximately 9,000 cases diagnosed annually in the United States. The average age…
Myeloproliferative Neoplasms and Myelodysplastic Syndromes Jad Chahoud Srdan Verstovsek Guillermo Garcia-Manero Hagop M. Kantarjian Elias Jabbour I. BCR-ABL1-NEGATIVE MYELOPROLIFERATIVE NEOPLASMS A. Overview The myeloproliferative neoplasms (MPNs) are clonal disorders of…
Chronic Leukemias Chaitra Ujjani Bruce D. Cheson I. INTRODUCTION Although the chronic leukemias have traditionally been grouped together to underscore their differences from the aggressive, acute leukemias, they are a…
Acute Leukemias Ashwin Kishtagari Olga Frankfurt Martin S. Tallman I. GENERAL FEATURES OF ACUTE LEUKEMIAS The acute leukemias are a heterogeneous group of disorders characterized by clonal proliferation and abnormal…
